Effects of subchronic treatment with O,O,S-trimethyl phosphorothioate on cellular and humoral immune response systems.
Effects of subchronic treatment with O,O,S-trimethyl phosphorothioate on cellular and humoral immune response systems.
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O,O,S-三甲基硫代磷酸酯亚慢性治疗对细胞和体液免疫反应系统的影响。
DOI：
10.1016/0041-008x(85)90168-1
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发表时间：
1985
影响因子：
3.8
通讯作者：
Devens,BH
中科院分区：
文献类型：
--
作者：
Rodgers,KE;Imamura,T;Devens,BH
用低剂量的O，O， s -三甲基磷硫酸（OOS-TMP）（技术马拉硫磷中的一种杂质）治疗14天，对雌性C57B1/6小鼠产生细胞介导和体液免疫应答的影响进行了研究。0.5 mg/kg/天的OOS-TMP剂量下，绵羊红细胞（SRBC）抗体分泌细胞的产生、白细胞介素2 （IL-2）的产生以及对丝裂原豆蛋白a （Con a）和脂多糖（LPS）的增殖反应升高。相比之下，细胞毒性t淋巴细胞（CTL）对同种异体抗原的反应没有变化。在5.0 mg/kg/天的OOS-TMP剂量下，CTL和特异性抗体反应均未发生变化，但所有其他免疫参数均升高。细胞分离和重组实验的数据表明，巨噬细胞和B细胞都受到这种治疗方案的影响。这些数据表明，长期暴露于低剂量的OOS-TMP可能会增强动物产生免疫反应的能力。
The effect of a 14-day treatment with low doses of O,O,S-Trimethyl phosphorothioate (OOS-TMP), an impurity in technical malathion, on the generation of cell-mediated and humoral immune responses was examined in female C57B1/6 mice. At a dose of 0.5 mg/kg/day OOS-TMP, the generation of antibody-secreting cells to sheep red blood cells (SRBC), the production of interleukin 2 (IL-2), and proliferative responses to the mitogens concanavalin A (Con A) and lipopolysaccharide (LPS) were elevated. In contrast, the cytotoxic T-lymphocyte (CTL) response to alloantigen was unchanged. At 5.0 mg/kg/day OOS-TMP, both the CTL and specific antibody response were unchanged, but all other immune parameters examined were elevated. Data from cell separation and reconstitution experiments indicated that both macrophages and B cells were affected by this treatment regime. These data suggest that long-term exposure to low amounts of OOS-TMP may enhance the ability of an animal to generate an immune response.