Cardiac Stem Cell Research: An Elephant in the Room?
Cardiac Stem Cell Research: An Elephant in the Room?
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DOI：
10.1002/ar.20858
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发表时间：
2009-03-01
影响因子：
2
通讯作者：
Zummo, Giovanni
中科院分区：
文献类型：
--
作者：
Di Felice, Valentina;De Luca, Angela;Zummo, Giovanni
心脏病是工业化国家死亡的主要原因，干细胞疗法似乎是治疗受损心脏组织的一种有前途的治疗方法。为了实现这一目标，科学界需要找到良好的干细胞来源，可用于在非常时期内获得新的心肌。由于使用胚胎干细胞作为具有心源性潜力的细胞来源存在许多伦理和技术问题，因此许多实验室尝试从多种组织中分离出潜在的心脏干细胞。最好的候选细胞似乎是心脏“祖细胞”和/或“干细胞”，它们可以从同一患者的心内膜下活组织检查中或从胚胎和/或胎儿心肌中分离出来。无论使用何种技术来分离和表征这些细胞，迄今为止从成体心肌中分离出的不同细胞似乎都是独特细胞类型的表型变异，该细胞类型以各种组合表达多种标记物，例如 c-Kit、CD34、MDR-1、Sca-1、CD45、巢蛋白或 Isl-1。 Anat Rec，292:449-454，2009。(C)2009 Wiley-Liss, Inc.
Heart disease is the leading cause of death in the industrialized world, and stem cell therapy seems to be a promising treatment for injured cardiac tissue. To reach this goal, the scientific community needs to find a good source of stem cells that can be used to obtain new myocardium in a very period range of time. Since there are many ethical and technical problems with using embryonic stem cells as a source of cells with cardiogenic potential, many laboratories have attempted to isolate potential cardiac stem cells from several tissues. The best candidates seem to be cardiac "progenitor" and/or "stem" cells, which can be isolated from subendocardial biopsies from the same patient or from embryonic and/or fetal myocardium. Regardless of the technique used to isolate and characterize these cells, it appears that the different cells isolated from adult myocardium to date are all phenotypic variations of a unique cell type that expresses several markers, such as c-Kit, CD34, MDR-1, Sca-1, CD45, nestin, or Isl-1, in various combinations. Anat Rec, 292:449-454, 2009. (C) 2009 Wiley-Liss, Inc.