Image-based estimation of ventricular fiber orientations for personalized modeling of cardiac electrophysiology.
Image-based estimation of ventricular fiber orientations for personalized modeling of cardiac electrophysiology.
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DOI：
10.1109/tmi.2012.2184799
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发表时间：
2012-05
影响因子：
10.6
通讯作者：
Trayanova N
中科院分区：
文献类型：
--
作者：
Vadakkumpadan F;Arevalo H;Ceritoglu C;Miller M;Trayanova N
技术上的局限性对心肌纤维定向的获取提出了重大挑战，用于患者特定的心脏功能建模和治疗评估。本项目的目的是开发一种方法来估计心脏纤维的方向，从患者心脏几何形状的体内图像。心室几何形状和纤维方向的准确表示重建，分别从高分辨率离体结构磁共振（MR）和扩散张量（DT）MR图像的正常人心脏，称为图集。通过半自动分割，从体内计算机断层扫描（CT）图像中提取患者心脏的心室几何形状。使用图像变换算法，使寰椎心室几何形状变形以匹配患者的形状。最后，将变形场应用于寰椎纤维方向，以获得患者纤维方向的估计。纤维估计的准确性进行了评估，使用六个正常和三个失败的犬心脏。所获得的纤维方向和估计的纤维方向的倾斜角之间的平均绝对差为15.4°。窦性心律和室性心动过速中心室激动标测图和伪ECG的计算模拟表明，在临床可观察水平上，估计和获取的纤维方向之间没有显著差异。
Technological limitations pose a major challenge to acquisition of myocardial fiber orientations for patient-specific modeling of cardiac (dys)function and assessment of therapy. The objective of this project was to develop a methodology to estimate cardiac fiber orientations from in vivo images of patient heart geometries. An accurate representation of ventricular geometry and fiber orientations was reconstructed, respectively, from high-resolution ex vivo structural magnetic resonance (MR) and diffusion tensor (DT) MR images of a normal human heart, referred to as the atlas. Ventricular geometry of a patient heart was extracted, via semiautomatic segmentation, from an in vivo computed tomography (CT) image. Using image transformation algorithms, the atlas ventricular geometry was deformed to match that of the patient. Finally, the deformation field was applied to the atlas fiber orientations to obtain an estimate of patient fiber orientations. The accuracy of the fiber estimates was assessed using six normal and three failing canine hearts. The mean absolute difference between inclination angles of acquired and estimated fiber orientations was 15.4°. Computational simulations of ventricular activation maps and pseudo-ECGs in sinus rhythm and ventricular tachycardia indicated that there are no significant differences between estimated and acquired fiber orientations at a clinically observable level.