Effects of cigarette smoking on the angiographic evolution of coronary atherosclerosis - A Canadian Coronary Atherosclerosis Intervention Trial (CCAIT) substudy
Effects of cigarette smoking on the angiographic evolution of coronary atherosclerosis - A Canadian Coronary Atherosclerosis Intervention Trial (CCAIT) substudy
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DOI：
10.1161/01.cir.94.4.614
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发表时间：
1996-08-15
期刊：
影响因子：
37.8
通讯作者：
Higginson, L
中科院分区：
文献类型：
--
作者：
Waters, D;Lesperance, J;Higginson, L
Background Although smoking increases both the risk of developing coronary disease and the risk of coronary events in patients with known coronary atherosclerosis, the effect of smoking on the evolution of coronary atherosclerosis as assessed by serial angiography is poorly defined.Methods and Results Ninety smokers with coronary atherosclerosis shown on a recent angiogram and with fasting cholesterol levels between 220 and 300 mg/dL were enrolled in a randomized, double-blind, placebo-controlled trial of cholesterol-lowering therapy, along with 241 nonsmokers and ex-smokers. Lovastatin at a mean dose of 36 mg/d lowered total and LDL cholesterol by 21+/-11% and 29+/-11%, respectively, but these levels changed by
