Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort
Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort
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DOI：
10.1002/ijc.29071
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发表时间：
2015-03-01
影响因子：
6.4
通讯作者：
Hesketh, John E.
中科院分区：
文献类型：
--
作者：
Hughes, David J.;Fedirko, Veronika;Hesketh, John E.
在欧洲的许多地方发现微量营养素硒（Se）的摄入量不足。低硒状态可能有助于结直肠癌（CRC）的发展。我们通过测定血清硒和硒蛋白P（SePP）水平来评估硒状态，并在欧洲癌症与营养前瞻性研究中采用巢式病例对照设计（966例CRC病例; 966例匹配对照）研究了与CRC风险的相关性。硒测定全反射X射线荧光和SePP免疫发光夹心法。采用条件Logistic回归计算多变量发病率比（IRR）和95%置信区间（CI）。硒和硒蛋白原分别为84.0 g/L和4.3 mg/L，对照组为85.6 g/L和4.4 mg/L。较高的硒浓度与CRC风险的非显著降低相关（IRR=0.92，95% CI：每增加25 g/L 0.82-1.03）。然而，按性别进行的亚组分析显示，女性（p（趋势）=0.032;每增加25 g/L硒，IRR=0.83，95% CI：0.70-0.97）存在统计学显著相关性，但男性则无。较高的SePP浓度与CRC风险呈负相关（p（趋势）=0.009;每增加0.806 mg/L，IRR=0.89，95% CI：0.82-0.98），女性中的相关性（p（趋势）=0.004; IRR=0.82，95% CI：每增加0.806 mg/L，0.72-0.94）比男性更明显（p（趋势）=0.485; IRR=0.98，95% CI：每增加0.806 mg/L，0.86-1.12）。研究结果表明，在许多欧洲人中，硒的状态是次优的，并表明CRC风险和较高的血清硒状态之间存在负相关，这在女性中更为明显。硒是一种具有抗癌特性的必需微量营养素，但其与结直肠癌发生的关系存在争议。在目前的研究中，作者发现许多西欧人的硒状态是次优的。较高的硒水平与结直肠癌的风险呈负相关，这一发现在女性中比男性更明显。作者认为，在硒状态次优的人群中（如西欧），增加硒摄入量可能会降低结直肠癌风险，而在硒摄入量较高的地区可能会获得相反的结果。
Suboptimal intakes of the micronutrient selenium (Se) are found in many parts of Europe. Low Se status may contribute to colorectal cancer (CRC) development. We assessed Se status by measuring serum levels of Se and Selenoprotein P (SePP) and examined the association with CRC risk in a nested case-control design (966 CRC cases; 966 matched controls) within the European Prospective Investigation into Cancer and Nutrition. Se was measured by total reflection X-ray fluorescence and SePP by immunoluminometric sandwich assay. Multivariable incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Respective mean Se and SePP levels were 84.0 g/L and 4.3 mg/L in cases and 85.6 g/L and 4.4 mg/L in controls. Higher Se concentrations were associated with a non-significant lower CRC risk (IRR=0.92, 95% CI: 0.82-1.03 per 25 g/L increase). However, sub-group analyses by sex showed a statistically significant association for women (p(trend)=0.032; per 25 g/L Se increase, IRR=0.83, 95% CI: 0.70-0.97) but not for men. Higher SePP concentrations were inversely associated with CRC risk (p(trend)=0.009; per 0.806 mg/L increase, IRR=0.89, 95% CI: 0.82-0.98) with the association more apparent in women (p(trend)=0.004; IRR=0.82, 95% CI: 0.72-0.94 per 0.806 mg/L increase) than men (p(trend)=0.485; IRR=0.98, 95% CI: 0.86-1.12 per 0.806 mg/L increase). The findings indicate that Se status is suboptimal in many Europeans and suggest an inverse association between CRC risk and higher serum Se status, which is more evident in women.What's new? Selenium is an essential micronutrient with anti-carcinogenic properties, but its association with the development of colorectal cancer is controversial. In the present study, the authors find that the selenium status in many Western Europeans is suboptimal. Higher selenium levels were inversely associated with the risk to develop colorectal carcinoma, a finding more evident in women than in men. The authors argue that in populations where the selenium status is sub-optimal (e.g. Western Europe) increasing selenium intake may reduce colorectal carcinoma risk, while contrasting results may be obtained in regions with higher selenium intake.