Gender differences in the neural correlates of response inhibition during a stop signal task
Gender differences in the neural correlates of response inhibition during a stop signal task
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DOI：
10.1016/j.neuroimage.2006.05.017
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发表时间：
2006-10-01
期刊：
影响因子：
5.7
通讯作者：
Sinha, Rajita
中科院分区：
文献类型：
--
作者：
Li, Chiang-shan Ray;Huang, Cong;Sinha, Rajita
我们使用功能磁共振成像来检验在停止信号任务中反应抑制的神经关联的性别差异。这项任务有一个频繁的“开始”信号，以建立一个预先有效的反应倾向，而不太频繁的“停止”信号，以阻止他们的反应。对个别受试者的成功和失败的抑制进行了大脑激活的对比。我们比较了在年龄、受教育年限和停车信号表现方面匹配的20名男性和20名女性，并将停车成功率、出错后减速和与任务相关的挫败感评级作为协变量。结果显示，与女性相比，男性在停止信号抑制期间，在广泛的皮质和皮质下区域，包括苍白球和运动丘脑，激活得更多。相比之下，即使在较低的统计门槛下，女性的大脑区域也没有表现出更大的激活。此外，当男性激活内侧额叶上叶和前扣带回皮质时，女性激活尾状尾部以调节反应抑制。这些结果扩大了认知运动任务中大脑区域激活到反应抑制的性别差异。男性激活了运动回路，而女性似乎参与了停车信号动作时的视觉联想或习惯学习。(C)2006 Elsevier Inc.保留所有权利。
We used functional magnetic resonance imaging to examine gender differences in the neural correlates of response inhibition during a stop signal task. The task has a frequent "go" signal to set up a pre-potent response tendency and a less frequent "stop" signal for subjects to withhold their response. A contrast in brain activation was made between successful and failed inhibitions for individual subjects. We compared 20 men and 20 women matched in age and years of education and in stop signal performance, with stop success rate, post-error slowing and task-related frustration ratings as covariates. The results showed greater activation in men, compared to women, in a wide array of cortical and subcortical areas, including the globus pallidus and motor thalamus during stop signal inhibition. In contrast, no brain regions demonstrated greater activation in women, even at a lower statistical threshold. Moreover, while men activated the medial superior frontal and anterior cingulate cortices, women activated the caudate tail to mediate response inhibition. These results extended gender differences in regional brain activation to response inhibition during a cognitive motor task. Men activated the motor circuitry while women appeared to involve visual association or habit learning during stop signal performance. (c) 2006 Elsevier Inc. All rights reserved.