Sodium Chloride Raises Blood Pressure in Normotensive Subjects The Study of Sodium and Blood Pressure
Sodium Chloride Raises Blood Pressure in Normotensive Subjects The Study of Sodium and Blood Pressure
复制标题
氯化钠会升高血压正常的受试者的血压 钠与血压的研究
作者：
S. Mascioli;R. Grimm;C. Launer;K. Svendsen;J. Flack;N. Gonzalez;P. Elmer;J. Neaton
饮食中钠对血压正常成人血压的影响还没有很好的特征。钠和血压研究（SNaP）是一项随机、双盲交叉试验，使用安慰剂或96 meq钠，治疗期为4周，间隔2周洗脱期。在胶囊治疗期之前，参与者被指导低钠饮食10周，以减少尿钠排泄量至低于35 meq/8 hr。在整个胶囊治疗期间，低钠饮食持续进行。受试者（n=48; 47例白色，1例黑人）为79%男性，平均年龄为52岁，体重指数为27.6，基线血压为131/84 mm Hg。在低钠饮食导入期后，胶囊治疗期开始前，基线过夜尿钠排泄量为51 meq/8 hr和19 meq/8 hr。在每次访视时以标准方式测量两次静息、坐位血压。钠和安慰剂治疗期之间的差异如下：收缩压分别为123.9和1203 mm Hg（p<0.001）;舒张压分别为78.7和76.4 mm Hg（p=0.005）;钠排泄量分别为513和30.9 meq/8 hr（p<0.001）。收缩压和舒张压增加显着量在血压正常的成年人的低钠饮食补充96 meq/天的钠。长期效应及量效关系有待进一步研究。
The effects of dietary sodium on blood pressure in normotensive adults is not well characterized. The Study of Sodium and Blood Pressure (SNaP) is a randomized, double-blind crossover trial using a placebo or 96 meq sodium in 4-week treatment periods separated by a 2-week washout period. Before capsule treatment periods, participants were instructed in a low sodium diet for 10 weeks to reduce urinary sodium excretion to less than 35 meq/8 hr. The low sodium diet was continued throughout the capsule treatment periods. Participants (n=48; 47 white, 1 black) were 79% male and had an average age of 52 years, a body mass index of 27.6, and a baseline blood pressure of 131/84 mm Hg. Baseline overnight urinary sodium excretion was 51 meq/8 hr and 19 meq/8 hr after the low sodium diet run-in period, before the capsule treatment periods began. Resting, seated blood pressure was measured twice at each visit in a standard fashion. Differences between sodium and placebo treatment periods were as follows: systolic blood pressure, 123.9 versus 1203 mm Hg, respectively p<0.001); diastolic blood pressure, 78.7 versus 76.4 mm Hg, respectively (p=0.005); and sodium excretion, 513 versus 30.9 meq/8 hr, respectively (p<0.001). Both systolic and diastolic blood pressures increased significant amounts in normotensive adults on a low sodium diet supplemented with 96 meq/day sodium. Long-term effects and doseresponse relations need further study.