Noggin
Noggin
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DOI：
10.1016/j.biocel.2011.01.007
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发表时间：
2011-04-01
影响因子：
4
通讯作者：
Knaus, Petra
中科院分区：
文献类型：
--
作者：
Krause, Carola;Guzman, Asja;Knaus, Petra
代谢原启动、促进和维持形态发生和成体组织稳态。骨形态发生蛋白（BMP）属于转化生长因子-β（TGF-β）超家族，代表调节外胚层、中胚层和内胚层衍生的组织形成的主要类别的代谢原。为了在时间和空间上控制BMP启动的信号级联反应，需要一个紧密的调控网络来维持和谐。有许多方法可以抑制或更可能修饰BMP信号传导，其中通过来自DAN-、扭曲原肠胚形成-、脊索蛋白-和头蛋白-家族的含半胱氨酸结的蛋白质的直接细胞外抑制是经典的。这篇评论的重点是noggin及其对BMP驱动的大量行动的影响，从而邀请不断增长的BMP研究领域（重新）详细调查noggin的功能。(C)2011爱思唯尔有限公司保留所有权利。
Metabologens initiate, promote and maintain morphogenesis and adult tissue homeostasis. Bone morphogenetic proteins (BMPs) which belong to the transforming growth factor-beta (TGF-beta) superfamily, represent a major class of metabologens that regulate ectoderm, mesoderm and endoderm derived tissue formation. In order to temporally and spatially control BMP initiated signaling cascades, a tight regulatory network is needed to maintain concinnity. There are a number of ways how BMP signaling can be inhibited or more likely be modified, among which the direct extracellular inhibition through cysteine-knot containing proteins from the DAN-, the twisted gastrulation-, chordin- and noggin-family is a classic. This review focuses on noggin and its impact on the vast array of BMP driven actions and thereby invites the ever-growing BMP research field to (re-) investigate noggin's function in detail. (C) 2011 Elsevier Ltd. All rights reserved.