RETINAL GANGLION-CELL ATROPHY CORRELATED WITH AUTOMATED PERIMETRY IN HUMAN EYES WITH GLAUCOMA
RETINAL GANGLION-CELL ATROPHY CORRELATED WITH AUTOMATED PERIMETRY IN HUMAN EYES WITH GLAUCOMA
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DOI：
10.1016/0002-9394(89)90488-1
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发表时间：
1989-05-15
影响因子：
4.2
通讯作者：
GREEN, WR
中科院分区：
文献类型：
--
作者：
QUIGLEY, HA;DUNKELBERGER, GR;GREEN, WR
我们测量了6只青光眼患者视网膜神经节细胞的数量和大小。在每种情况下，组织学结果与视野结果相关。五个年龄匹配的正常眼进行了比较研究。一般来说，在萎缩的视网膜区域中剩余的大神经节细胞较少。然而，在中央凹周围区域，没有一致的细胞损失模式的大小被发现。我们的估计表明，在自动化测试视野灵敏度开始下降后不久，最初的损失神经节细胞。在视网膜中央30度的范围内，敏感度损失5 dB的位置消失了20%的正常细胞数量，而40%的细胞损失对应于10 dB的下降。有一些剩余的神经节细胞的领域，有0分贝的灵敏度在现场测试。
We measured the number and size of retinal ganglion cells from six human eyes with glaucoma. In each, the histologic findings were correlated with visual field results. Five age-matched normal eyes were studied for comparison. In general, there were fewer remaining large ganglion cells in retinal areas with atrophy. In the perifoveal area, however, no consistent pattern of cell loss by size was found. Our estimates suggest that visual field sensitivity in automated testing begins to decline soon after the initial loss of ganglion cells. Throughout the central 30 degrees of the retina, 20% of the normal number of cells were gone in locations with a 5-dB sensitivity loss, and 40% cell loss corresponded to a 10-dB decrease. There were some remaining ganglion cells in areas that had 0-dB sensitivity in the field test.