Global circulation patterns of seasonal influenza viruses vary with antigenic drift.
Global circulation patterns of seasonal influenza viruses vary with antigenic drift.
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DOI：
10.1038/nature14460
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发表时间：
2015-07-09
期刊：
影响因子：
64.8
通讯作者：
Russell, Colin A.
中科院分区：
文献类型：
--
作者：
Bedford, Trevor;Riley, Steven;Barr, Ian G.;Broor, Shobha;Chadha, Mandeep;Cox, Nancy J.;Daniels, Rodney S.;Gunasekaran, C. Palani;Hurt, Aeron C.;Kelso, Anne;Klimov, Alexander;Lewis, Nicola S.;Li, Xiyan;McCauley, John W.;Odagiri, Takato;Potdar, Varsha;Rambaut, Andrew;Shu, Yuelong;Skepner, Eugene;Smith, Derek J.;Suchard, Marc A.;Tashiro, Masato;Wang, Dayan;Xu, Xiyan;Lemey, Philippe;Russell, Colin A.
了解新的人类季节性流感病毒变种出现和传播的时空模式是一项关键的科学和公共卫生挑战。甲型/H3 N2流感病毒的全球传播模式已得到很好的表征，但甲型/H1 N1和B病毒的模式仍基本上未被探索。在此，基于对2000-2012年期间9，604个人类季节性流感病毒的血凝素序列的分析，我们表明A/H1N1（截至2009年）、B/维多利亚和B/Yamagata病毒的全球传播模式与A/H3 N2病毒有很大不同。虽然甲型H3 N2病毒的遗传变异在两次流行之间并没有在当地持续存在，而是从东亚和东南亚（E-SE）重新传播，但甲型H1 N1和B病毒的遗传变异在多个季节持续存在，并表现出复杂的全球动态，而东亚和东南亚在传播新变异方面发挥的作用有限。与A/H3 N2病毒相比，A/H1N1和B流感病毒的全球移动频率较低，这与抗原进化速度较慢、感染年龄较低以及流行频率较低的规模相吻合。详细的流行病模型支持感染年龄的差异，加上儿童旅行的频率较低，这可能是全球传播模式差异的驱动因素，表明病毒进化，流行病学和人类行为之间存在复杂的相互作用。
Understanding the spatio-temporal patterns of emergence and circulation of new human seasonal influenza virus variants is a key scientific and public health challenge. The global circulation patterns of influenza A/H3N2 viruses are well-characterized but the patterns of A/H1N1 and B viruses have remained largely unexplored. Here, based on analyses of 9,604 hemagglutinin sequences of human seasonal influenza viruses from 2000–2012, we show that the global circulation patterns of A/H1N1 (up to 2009), B/Victoria, and B/Yamagata viruses differ substantially from those of A/H3N2 viruses. While genetic variants of A/H3N2 viruses did not persist locally between epidemics and were reseeded from East and Southeast (E-SE) Asia, genetic variants of A/H1N1 and B viruses persisted across multiple seasons and exhibited complex global dynamics with E-SE Asia playing a limited role in disseminating new variants. The less frequent global movement of influenza A/H1N1 and B viruses coincided with slower rates of antigenic evolution, lower ages of infection, and smaller less frequent epidemics compared to A/H3N2 viruses. Detailed epidemic models support differences in age of infection, combined with the less frequent travel of children, as likely drivers of the differences in the patterns of global circulation, suggesting a complex interaction between virus evolution, epidemiology and human behavior.
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DOI：
10.1016/j.cub.2011.05.058
发表时间：
2011-08-09
期刊：
Current biology : CB
影响因子：
--
作者：
Edwards CJ;Suchard MA;Lemey P;Welch JJ;Barnes I;Fulton TL;Barnett R;O'Connell TC;Coxon P;Monaghan N;Valdiosera CE;Lorenzen ED;Willerslev E;Baryshnikov GF;Rambaut A;Thomas MG;Bradley DG;Shapiro B
通讯作者：
Shapiro B
影响因子：
2
作者：
Lin, J;Andreasen, V;Levin, SA
通讯作者：
Levin, SA
影响因子：
64.8
作者：
Rambaut, Andrew;Pybus, Oliver G.;Holmes, Edward C.
通讯作者：
Holmes, Edward C.
影响因子：
5.4
作者：
Bedford T;Rambaut A;Pascual M
通讯作者：
Pascual M
影响因子：
4.3
作者：
Lemey P;Rambaut A;Drummond AJ;Suchard MA
通讯作者：
Suchard MA