Creation of genomic methylation patterns
Creation of genomic methylation patterns
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DOI：
10.1038/ng0496-363
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发表时间：
1996-04-01
期刊：
影响因子：
30.8
通讯作者：
Tycko, B
中科院分区：
文献类型：
--
作者：
Bestor, TH;Tycko, B
基因组甲基化模式有两个生物学特性可以被认为是已建立的。首先，启动子内5 '-CpG-3'二核苷酸的甲基化抑制转录，通常抑制到不可检测的水平。其次，在大多数情况下，甲基化模式受克隆遗传的影响。这些性质适合甲基化模式的一些生物学作用，虽然没有一个目前的假设可以被视为证明或反驳。一种假说认为，寄生序列元件的活性被选择性甲基化抑制。入侵序列，可能允许他们的识别和失活的功能进行了讨论的基因组防御假说。直接从头甲基化的线索的鉴定可以揭示基因组甲基化模式的生物学作用。
There are two biological properties of genomic methylation patterns that can be regarded as established. First, methylation of 5'-CpG-3' dinucleotides within promoters represses transcription, often to undetectable levels. Second, in most cases methylation patterns are subject to clonal inheritance. These properties suit methylation patterns for a number of biological roles, although none of the current hypotheses can be regarded as proved or disproved. One hypothesis suggests that the activity of parasitic sequence elements is repressed by selective methylation. Features of invasive sequences that might allow their identification and inactivation are discussed in terms of the genome defense hypothesis. Identification of the cues that direct de novo methylation may reveal the biological role (or roles) of genomic methylation patterns.