Total Syntheses of Bisdehydroneostemoninine and Bisdehydrostemoninine by Catalytic Carbonylative Spirolactonization.
Total Syntheses of Bisdehydroneostemoninine and Bisdehydrostemoninine by Catalytic Carbonylative Spirolactonization.
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DOI：
10.1002/anie.201809114
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发表时间：
2018-11-12
期刊：
影响因子：
--
通讯作者：
Dai M
中科院分区：
文献类型：
--
作者：
Ma K;Yin X;Dai M
The first total syntheses of stemona alkaloids bisdehydroneostemoninine and bisdehydrostemoninine in racemic forms have been achieved. The synthetic strategy features a novel palladium-catalyzed carbonylative spirolactonization of hydroxycyclopropanol 8 to rapidly build the oxaspirolactone moiety and a Lewis acid-promoted tandem Friedel-Crafts cyclization and lactonization of 13 to form the 5-7-5 tricyclic core of the target stemona alkaloids. The first total syntheses of stemona alkaloids bisdehydroneostemoninine and bisdehydrostemoninine were reported. The synthesis features a novel palladium-catalyzed carbonylative spirolactonization to rapidly build their oxaspirolactone moiety and a Lewis acid-promoted tandem Friedel-Crafts cyclization and lactonization to form the 5-7-5 tricyclic core of the target stemona alkaloids.
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影响因子：
5.1
作者：
Lin, Li-Gen;Li, Kan Man;Ye, Yang
通讯作者：
Ye, Yang
影响因子：
3.6
作者：
Bates, Roderick W.;Sridhar, S.
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影响因子：
2.1
作者：
Kakuta, D;Hitotsuyanagi, Y;Takeya, K
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Takeya, K
DOI：
10.1073/pnas.1016558108
发表时间：
2011-04-26
影响因子：
11.1
作者：
Frankowski, Kevin J.;Setola, Vincent;Aube, Jeffrey
通讯作者：
Aube, Jeffrey
影响因子：
1.8
作者：
Gourlay, BS;Molesworth, PP;Smith, JA
通讯作者：
Smith, JA