Current Perspectives of Telomerase Structure and Function in Eukaryotes with Emerging Views on Telomerase in Human Parasites.
Current Perspectives of Telomerase Structure and Function in Eukaryotes with Emerging Views on Telomerase in Human Parasites.
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DOI：
10.3390/ijms19020333
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发表时间：
2018-01-24
影响因子：
5.6
通讯作者：
Chakrabarti K
中科院分区：
文献类型：
--
作者：
Dey A;Chakrabarti K
细胞的复制能力与端粒长度调节密切相关。端粒长度的异常延长或缩短可能导致健康异常，例如癌症或过早衰老。端粒酶是维持大多数真核细胞复制潜力的主要调节因子。它通过控制染色体末端的端粒长度来实现这一点。与癌细胞类似，大多数单细胞真核病原体具有高度增殖性，需要持续的端粒酶活性来维持端粒长度恒定并在宿主体内增殖。尽管在这两种情况下端粒酶都是无限细胞增殖的关键，但直到最近人们对端粒酶在人类寄生虫（疟疾、锥虫等）中的作用知之甚少。由于端粒酶调节是通过其自身的结构成分、与催化逆转录酶的相互作用以及能够以细胞周期依赖性方式将端粒酶募集和组装到端粒的几种因素介导的，因此我们在此比较和讨论癌症、衰老和寄生虫病中端粒酶生物学的最新发现，以更广泛地了解端粒酶在人类疾病中的功能。
Replicative capacity of a cell is strongly correlated with telomere length regulation. Aberrant lengthening or reduction in the length of telomeres can lead to health anomalies, such as cancer or premature aging. Telomerase is a master regulator for maintaining replicative potential in most eukaryotic cells. It does so by controlling telomere length at chromosome ends. Akin to cancer cells, most single-cell eukaryotic pathogens are highly proliferative and require persistent telomerase activity to maintain constant length of telomere and propagation within their host. Although telomerase is key to unlimited cellular proliferation in both cases, not much was known about the role of telomerase in human parasites (malaria, Trypanosoma, etc.) until recently. Since telomerase regulation is mediated via its own structural components, interactions with catalytic reverse transcriptase and several factors that can recruit and assemble telomerase to telomeres in a cell cycle-dependent manner, we compare and discuss here recent findings in telomerase biology in cancer, aging and parasitic diseases to give a broader perspective of telomerase function in human diseases.
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DOI：
10.1073/pnas.95.15.8479
发表时间：
1998-07-21
影响因子：
11.1
作者：
Bryan, TM;Sperger, JM;Cech, TR
通讯作者：
Cech, TR
端粒DNA合成过程中端粒酶RNA定位的RNA手风琴模型。
影响因子：
16.8
作者：
Berman, Andrea J.;Akiyama, Benjamin M.;Stone, Michael D.;Cech, Thomas R.
通讯作者：
Cech, Thomas R.
影响因子：
14.9
作者：
Brown Y;Abraham M;Pearl S;Kabaha MM;Elboher E;Tzfati Y
通讯作者：
Tzfati Y
影响因子：
4.8
作者：
Bosoy, D;Peng, Y;Lue, NF
通讯作者：
Lue, NF
影响因子：
3.3
作者：
Bachand, F;Boisvert, FM;Autexier, C
通讯作者：
Autexier, C