ELEVATED NEUTROPHIL FUNCTION IN CHRONIC NEUTROPHILIC LEUKEMIA
ELEVATED NEUTROPHIL FUNCTION IN CHRONIC NEUTROPHILIC LEUKEMIA
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DOI：
10.1002/ajh.2830410110
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发表时间：
1992-09-01
影响因子：
12.8
通讯作者：
MOTOYOSHI, K
中科院分区：
文献类型：
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作者：
OHTSUKI, T;KATSURA, Y;MOTOYOSHI, K
65岁男性，白细胞明显增多，入院诊治。他的外周血白细胞计数为37500 / μ l，白细胞由成熟的中性粒细胞样细胞组成。中性粒细胞碱性磷酸酶评分高，骨髓细胞核型正常，提示患者为慢性中性粒细胞白血病，而非慢性髓性白血病。一些中性粒细胞功能，如超氧化物的产生、硝基蓝四氮唑还原活性和吞噬活性均升高。这些数据和形态学特征（毒性颗粒和Dohle小体）表明患者的中性粒细胞处于活化阶段。
A 65-year-old man with marked leukocytosis was admitted for diagnosis and treatment. His peripheral blood leukocyte count was 37,500/mu-l and the leukocytes consisted of mature neutrophil-like cells. A high neutrophil alkaline phosphatase score and a normal bone marrow cell karyotype suggested that the patient had chronic neutrophilic leukemia rather than chronic myeloid leukemia. Several neutrophil functions, such as superoxide production, nitroblue tetrazolium reduction activity, and phagocytosis, were elevated. These data and the morphological features (toxic granules and Dohle bodies) indicated that the patient's neutrophils were in an activated stage.