Hormone rhythms and breast cancer chronoepidemiology: salivary progesterone concentrations in pre- and post-menarchal girls and in normal premenopausal women.
Hormone rhythms and breast cancer chronoepidemiology: salivary progesterone concentrations in pre- and post-menarchal girls and in normal premenopausal women.
复制标题
激素节律和乳腺癌时间流行病学：初潮前和初潮后女孩以及正常绝经前妇女的唾液黄体酮浓度。
DOI：
10.3109/07420528409059134
复制
发表时间：
1984
影响因子：
2.8
通讯作者：
K. Griffiths
中科院分区：
文献类型：
--
作者：
D. Wilson;G. Read;I. Hughes;R. Walker;K. Griffiths
月经前期和青春期女孩和健康成熟的绝经前妇女的唾液孕酮水平的昼夜节律和circatrigintan时间序列已被研究作为乳腺癌风险的一个可能的决定因素。孕酮的昼夜节律变化似乎是随机的，而不是系统的，每日孕酮总产量的估计值更好地代表了从几个2小时标本汇集的样本。不同模式的circatrigintan孕激素分泌的女孩是公认的，并与不孕和生育妇女的经验，虽然他们的关系，实足年龄或月经年龄尚未确定。这些数据表明，测量唾液孕酮在初潮前，青春期和成熟期是一个可行的，但统计学上很难，前瞻性的研究，识别个人的乳腺癌的风险。
Circadian and circatrigintan time series of salivary progesterone levels in premenarchal and adolescent girls and healthy mature premenopausal women have been investigated as a possible determinant for breast cancer risk. Circadian variations in progesterone appear to be more random than systematic and estimates of total daily progesterone output are better represented by samples pooled from several 2-hr specimens. Different patterns of circatrigintan progesterone secretion in girls are recognised and relate to those experienced in infertile and fertile women, though their relation to chronological or menarchal age is as yet uncertain. These data suggest that the measurement of salivary progesterone at premenarche, adolescence and maturity is a feasible, though statistically difficult, study for prospective identification of individuals at risk for breast cancer.