Chronic psychological stress and the regulation of pro-inflammatory cytokines: A glucocorticoid-resistance model
Chronic psychological stress and the regulation of pro-inflammatory cytokines: A glucocorticoid-resistance model
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DOI：
10.1037//0278-6133.21.6.531
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发表时间：
2002-11-01
影响因子：
4.2
通讯作者：
Ritchey, AK
中科院分区：
文献类型：
--
作者：
Miller, GE;Cohen, S;Ritchey, AK
这项研究检测了慢性压力是否会损害免疫系统对终止炎症的激素信号做出反应的能力。研究对象为50名健康成年人，其中一半是癌症患者的父母，另一半是健康儿童的父母。癌症患者的父母比健康儿童的父母报告更多的心理困扰。他们的皮质醇分泌昼夜斜率也较平坦，主要是因为早上的分泌量减少。还有证据表明，慢性压力损害了免疫系统对抗炎信号的反应：在癌症患者的父母中，合成糖皮质激素抑制促炎细胞因子白细胞介素-6体外产生的能力减弱。研究结果表明，慢性压力可能会改变炎症性疾病的进程的新途径。
This study examined whether chronic stress impairs the immune system's capacity to respond to hormonal signals that terminate inflammation. Fifty healthy adults were studied; half were parents of cancer patients, and half were parents of healthy children. Parents of cancer patients reported more psychological distress than parents of healthy children. They also had flatter diurnal slopes of cortisol secretion, primarily because of reduced output during the morning hours. There was also evidence that chronic stress impaired the immune system's response to anti-inflammatory signals: The capacity of a synthetic glucocorticoid hormone to suppress in vitro production of the pro-inflammatory cytokine interleukin-6 was diminished among parents of cancer patients. Findings suggest a novel pathway by which chronic stress might alter the course of inflammatory disease.