Solid-phase micro-extraction-gas chromatography-(tandem) mass spectrometry as a tool for pesticide residue analysis in water samples at high sensitivity and selectivity with confirmation capabilities
Solid-phase micro-extraction-gas chromatography-(tandem) mass spectrometry as a tool for pesticide residue analysis in water samples at high sensitivity and selectivity with confirmation capabilities
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DOI：
10.1016/j.chroma.2003.10.117
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发表时间：
2004-02-13
影响因子：
4.1
通讯作者：
Alpendurada, MF
中科院分区：
文献类型：
--
作者：
Gonçalves, C;Alpendurada, MF
气相色谱-质谱法(GC-MS)以其高灵敏度、高特异性和多残留、多类别分析的潜力，在农药监测中得到了广泛应用。建立了固相微萃取(SPME)与气相色谱-离子捕集-质谱仪联用测定水样中多种农药残留的分析方法。对于固相微萃取，选择了聚二甲基硅氧烷-二乙烯基苯涂层纤维，而质谱仪分别在全扫描、选择离子存储(SIS)、MUSIS(SIM)和MS-MS下运行，并比较了优值系数。讨论了每种运行模式的定量和定性(确证)能力。与MUSIS相比，MS-MS的精密度通常低于10%，检测限(LOD)提高了1.3-20倍(低或低于ppt水平)，同时保持了识别能力。固相微萃取与GC-MS-MS高选择性测定相结合，使复杂环境样品中农药的超选择性和基本无误差测定成为可能。这一方面将在论文中予以重点介绍。(C)2003爱思唯尔B.V.保留所有权利。
Gas chromatography-mass spectrometry (GC-MS) has been widely applied for pesticide monitoring because of its high sensitivity and specificity and for the potential of multi-residue and multi-class analysis. An analytical procedure was developed for the determination of pesticide multi-residues in water samples combining solid-phase micro-extraction (SPME) and gas chromatography-ion trap mass spectrometry. For SPME extraction a poly(dimethylsiloxane)-divinylbenzene coated fibre was selected whereas the mass spectrometer was operated under full scan, selected ion storage (SIS), muSIS (SIM) and MS-MS and the figures of merit compared. Quantitative and qualitative (confirmatory) capabilities of each operation mode are discussed. Using MS-MS, precision was typically below 10% and limits of detection (LODs) were improved by 1.3 to 20 times (to low- or sub-ppt levels) compared to muSIS, with the advantage of maintaining identification capabilities. The combination of selective extraction by SPME and highly selective determination by GC-MS-MS made possible ultra-selective and essentially error-free determination of pesticides in complex environmental samples. This aspect will be highlighted in the paper. (C) 2003 Elsevier B.V. All rights reserved.