Impact of prenatal cannabis exposure on functional connectivity of the salience network in children
Impact of prenatal cannabis exposure on functional connectivity of the salience network in children
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DOI：
10.1002/jnr.25136
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发表时间：
2022-10-13
影响因子：
4.2
通讯作者：
Marusak, Hilary A.
中科院分区：
文献类型：
--
作者：
Faraj, Mohammed M.;Evanski, Julia;Marusak, Hilary A.
在过去十年中，孕妇使用大麻的情况有所增加。这是令人担忧的，因为产前大麻暴露（PCE）与后代的认知，运动和社会缺陷有关。在这里，我们研究了休息状态功能连接（rsFC）的显着性网络（SN）-核心神经认知网络，整合情感和感觉信息-在儿童（与没有）PCE。使用从青少年脑认知发育研究中收集的10，719名儿童（M +/- SD = 9.92 +/- 0.62岁; 47.9%为女性）的神经影像学和发育史数据，我们评估了父母报告的PCE（怀孕知识之前或之后）对SN和其他五个核心神经认知网络内和之间的rsFC的影响。我们还评估了SN rsFC是否介导PCE和儿童精神病理学之间的关联。结果表明，PCE之前（而不是之后）的知识怀孕与较低的SN腹侧注意网络（货车）rsFC。此外，精神病样经历介导PCE和SN-VAN rsFC之间的关联，并且模型的逆转也是显著的，使得SN-VAN rsFC介导PCE和精神病样症状之间的关联。然而，在纳入协变量后，这些中介效应不再显著。综上所述，这些研究结果表明，SN-VAN相互作用的发育改变可能解释了先前报道的PCE与儿童精神病理学风险升高之间的关联。
Cannabis use among pregnant people has increased over the past decade. This is of concern as prenatal cannabis exposure (PCE) is associated with cognitive, motor, and social deficits among offspring. Here, we examined resting-state functional connectivity (rsFC) of the salience network (SN)-a core neurocognitive network that integrates emotional and sensory information-in children with (vs. without) PCE. Using neuroimaging and developmental history data collected from 10,719 children (M +/- SD = 9.92 +/- 0.62 years; 47.9% female) from the Adolescent Brain Cognitive Development study, we assessed the impact of parent-reported PCE (before or after knowledge of pregnancy) on rsFC within and between the SN and five other core neurocognitive networks. We also evaluated whether SN rsFC mediated the association between PCE and child psychopathology. Results showed that PCE before (but not after) knowledge of pregnancy was associated with lower SN-ventral attention network (VAN) rsFC. Furthermore, psychotic-like experiences mediated the association between PCE and SN-VAN rsFC, and reversal of the model was also significant, such that SN-VAN rsFC mediated the association between PCE and psychotic-like symptoms. However, these mediation effects were no longer significant after the inclusion of covariates. Taken together, these findings suggest that developmental alterations in SN-VAN interactions may explain the previously reported association between PCE and elevated risk of child psychopathology.