Oocyte development in Hydra involves selection from competent precursor cells
Oocyte development in Hydra involves selection from competent precursor cells
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DOI：
10.1006/dbio.2000.9790
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发表时间：
2000-08-15
影响因子：
2.7
通讯作者：
Steele, RE
中科院分区：
文献类型：
--
作者：
Miller, MA;Technau, U;Steele, RE
我研究了普通水螅卵母细胞的发育，普通水螅是最古老的后生动物门之一。我们表明，卵母细胞的决定涉及一种机制，建立一个子集的前体间质细胞有能力分化成卵母细胞。卵母细胞从该亚群中挑选出来，并且剩余细胞成为卵母细胞的能力随着它们采用替代的保育细胞命运而显著降低。通过护士细胞分化程序的进展需要卵母细胞的存在。当卵母细胞被从卵子中取出时，保育细胞中止其分化程序，经历凋亡，并被体细胞上皮细胞吞噬和降解。然而，在卵母细胞的存在下，保育细胞分化并进入不寻常的凋亡程序，其中它们被卵母细胞吞噬，但不降解。我们表明，卵母细胞能够诱导这种不寻常的凋亡程序在未成熟的护士细胞尚未完成分化。本文讨论了水螅卵母细胞发育的一种新模式。(C)北京大学出版社.
me have investigated oocyte development in Hydra vulgaris, a member of one of the oldest metazoan phyla. We show that oocyte determination involves a mechanism that establishes a subset of precursor interstitial cells competent to differentiate into oocytes. The oocyte is singled out from this subset and the competence of the remaining cells to become oocytes dramatically decreases as they adopt the alternative nurse cell fate. Progression through the nurse cell differentiation program requires the presence of the oocyte. When the oocyte is removed from the egg held, nurse cells abort their differentiation program, undergo apoptosis, and are phagocytosed and degraded by somatic epithelial cells. However, in the presence of the oocyte, nurse cells differentiate and enter an unusual apoptosis program where they are phagocytosed by the oocyte, but are not degraded. We show that the oocyte is able to induce this unusual apoptosis program in immature nurse cells that have not completed differentiation. A new model for oocyte development in Hydra is discussed. (C) 2000 Academic Press.