Hepatocellular oncofetal protein, glypican 3 is a sensitive marker for α-fetoprotein-producing gastric carcinoma
Hepatocellular oncofetal protein, glypican 3 is a sensitive marker for α-fetoprotein-producing gastric carcinoma
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DOI：
10.1111/j.1365-2559.2006.02522.x
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发表时间：
2006-11-01
期刊：
影响因子：
6.4
通讯作者：
Fukayama, M.
中科院分区：
文献类型：
--
作者：
Hishinuma, M.;Ohashi, K-I;Fukayama, M.
Glypical3(GPC3)是一种细胞表面硫酸乙酰肝素蛋白多糖，特异性表达于胎肝和恶性肿瘤的肝细胞系。为探讨GPC3在甲胎蛋白(AFP)产生的胃癌和其他类型的GC中的意义，我们用免疫组织化学方法检测了GPC3在AFP产生的胃癌和具有其他肝细胞系标志(AFP、Pivka-II和肝细胞抗原，HEP)的一系列GC组织芯片中的表达。在10例AFP阳性的胃癌中，GPC3、PIVKA-II和HEP分别在10例、3例和3例肝样成分和9例非肝样成分中呈阳性表达。118例胃癌中，AFP阳性1例(0.8%)，GPC3阳性4例(3.4%)，Pivka-II阳性6例(5.1%)，HEP阳性26例(22%)。GPC3与AFP同时出现，与PIVKA-II、HEP不一致。与AFP免疫反应相比，GPC3在更大范围内的阳性率明显高于AFP。GPC3是产生AFP的GC及其肝样成分的敏感标记物，因此有助于识别这一侵袭性GC亚群。
Glypican 3 (GPC3) is a cell surface heparan sulphate proteoglycan expressed specifically in the fetal liver and malignant neoplasms of hepatocyte lineage. The aim was to evaluate the significance of GPC3 in alpha-fetoprotein (AFP)-producing gastric carcinoma (GC) and other forms of GC.We immunohistochemically evaluated GPC3 expression in representative cases of AFP-producing GC and in a tissue microarray of a consecutive series of GCs with other markers of hepatocyte lineage (AFP, PIVKA-II and hepatocyte antigen, HEP). In a series of 10 cases of AFP-producing GC, we observed immunohistochemical positivity for GPC3, PIVKA-II and HEP in 10, three and three cases in components with a hepatoid pattern and in nine, two and five cases in components with a non-hepatoid pattern, respectively. In a series of 118 cases of GC, we observed positivity for AFP, GPC3, PIVKA-II and HEP in one (0.8%), four (3.4%), six (5.1%) and 26 cases (22%), respectively. GPC3 was observed concurrently with AFP and discordantly with PIVKA-II and HEP. GPC3 positivity was clearly stronger in a larger area compared with immunoreactivity for AFP.GPC3 is a sensitive marker for AFP-producing GC and its hepatoid component and is therefore useful to identify this aggressive subgroup of GC.