Examining the association between blood-based biomarkers and human post mortem neuropathology in the University of Kentucky Alzheimer's Disease Research Center autopsy cohort.
Examining the association between blood-based biomarkers and human post mortem neuropathology in the University of Kentucky Alzheimer's Disease Research Center autopsy cohort.
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在肯塔基大学阿尔茨海默病研究中心尸检队列中检查血液生物标志物与人类死后神经病理学之间的关联。
DOI：
10.1002/alz.12639
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Wilcock,DonnaM
中科院分区：
文献类型：
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作者：
Winder,Zachary;Sudduth,TiffanyL;Anderson,Sonya;Patel,Ela;Neltner,Janna;Martin,BarbaraJ;Snyder,KatherineE;Abner,ErinL;Jicha,GregoryA;Nelson,PeterT;Wilcock,DonnaM
前言临床上，检测与阿尔茨海默病(AD)和认知损害和痴呆(VCID)的血管贡献相关的致病病理仅限于磁共振成像和正电子发射断层扫描，这些扫描费用昂贵，而且不能广泛获得。在这里，我们评估血管生成、炎症和AD相关的血浆生物标记物，以确定它们与人类尸检后神经病理学的关系。方法血浆样本使用数字免疫分析进行分析，病理评估由肯塔基大学阿尔茨海默病研究中心神经病理学家进行。结果90例AD患者血浆Tau/Aβ42比值升高，胶质纤维酸性蛋白、血管内皮生长因子A、胎盘生长因子A、胎盘生长因子A与AD神经病变程度呈正相关，而Aβ42/Aβ40比值与AD神经病变程度呈负相关。β42/Aβ40比值与慢性脑血管疾病呈负相关，而血浆标志物作为AD和VCID病理的临床筛查工具的研究结果提供了支持。
IntroductionClinically, detection of disease‐causing pathology associated with Alzheimer's disease (AD) and vascular contributions to cognitive impairment and dementia (VCID) is limited to magnetic resonance imaging and positron emission tomography scans, which are expensive and not widely accessible. Here, we assess angiogenic, inflammatory, and AD‐related plasma biomarkers to determine their relationships with humanpost mortemneuropathology.MethodPlasma samples were analyzed using a digital immunoassay and pathological evaluation was performed by University of Kentucky Alzheimer's Disease Research Center neuropathologists. The association of plasma markers with neuropathology was estimated via proportional odds and logistic regressions adjusted for age.ResultsIncluded cases (N = 90) showed increased tau/amyloid beta (Aβ)42 ratio, glial fibrillary acidic protein (GFAP), vascular endothelial growth factor A (VEGF‐A), and placental growth factor (PlGF) were positively associated with higher level of AD neuropathological change, while higher Aβ42/Aβ40 ratio was inversely associated. Higher PlGF, VEGF‐A, and interleukin 6 were inversely associated with chronic cerebrovascular disease, while Aβ42/Aβ40 ratio was positively associated.DiscussionOur results provide support for the continued study of plasma biomarkers as a clinical screening tool for AD and VCID pathology.