ORAL-ADMINISTRATION OF TRITIATED-WATER (HTO) IN MOUSE .2. TUMOR-DEVELOPMENT
ORAL-ADMINISTRATION OF TRITIATED-WATER (HTO) IN MOUSE .2. TUMOR-DEVELOPMENT
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DOI：
10.1080/09553009514550911
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发表时间：
1995-07-01
影响因子：
2.6
通讯作者：
KINOMURA, A
中科院分区：
文献类型：
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作者：
YAMAMOTO, O;SEYAMA, T;KINOMURA, A
以前，我们报告的造血死亡的影响，氚水（HTO）在饮用水中的浓度范围从5。92 X 10（11）到1。85 X 10（10）Bq/dm（3）。在本研究中，HTO在较低浓度范围内的影响，从9。25 X 10（9）Bq/dm（3）（0 . 240戈伊/天）至3 . 70 X 10（8）Bq/dm（3）（0 . 096戈伊/天）。雌性（C57 BL/6 N和C3 H/He）F-1小鼠保持饮用含有各种水平HTO的饮用水。小鼠存活> 150天，肿瘤发生率高（70 - 80%）。在剂量率范围从9。25 X 10（9）Bq/dm（3）（0 . 240戈伊/天）至1 . 85 X 10（9）Bq/dm（3）（0 .胸腺淋巴瘤是主要死亡原因。然而，在剂量率为9。25 X 10（8）Bq/dm（3）（0 .戈伊/天），胸腺淋巴瘤发病率明显下降，而其他肿瘤发病率上升。肿瘤类型在较低浓度的HTO下变得更加多样化。在这项研究中，H-3 β照射的肿瘤发展潜伏期较短，缩短寿命的效果比其他研究中报道的X或γ照射更明显。
Previously we reported haematopoietic death as an effect of tritiated water (HTO) in drinking water in the concentration range from 5 . 92 X 10(11) to 1 . 85 X 10(10) Bq/dm(3). In the present study the effects of HTO in a lower concentration range from 9 . 25 X 10(9) Bq/dm(3) (0 . 240 Gy/day) to 3 . 70 X 10(8) Bq/dm(3) (0 . 096 Gy/day) are reported. Female (C57BL/6N and C3H/He)F-1 mice were maintained on drinking water containing various levels of HTO. Mice survived for > 150 days with a high incidence of tumour development (70 to 80%). In the dose-rate range from 9 . 25 X 10(9) Bq/dm(3) (0 . 240 Gy/day) to 1 . 85 X 10(9) Bq/dm(3) (0 . 048 Gy/day) the main cause of death was thymic lymphoma. However, at a dose-rate of 9 . 25 X 10(8) Bq/dm(3) (0 . 024 Gy/day) the incidence of thymic lymphoma sharply decreased, while the incidence of other tumours increased. The tumour types became more diverse at lower concentrations of HTO. The latent period of tumour development was shorter and the life-shortening effect was more marked by H-3 beta-irradiation in this study than by X- or gamma-irradiation reported in other investigations.