The ventricular epicardial fat is related to the myocardial mass in normal, ischemic and hypertrophic hearts
The ventricular epicardial fat is related to the myocardial mass in normal, ischemic and hypertrophic hearts
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DOI：
10.1016/j.carpath.2004.08.005
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发表时间：
2004-11-01
影响因子：
3.7
通讯作者：
Bordi, C
中科院分区：
文献类型：
--
作者：
Corradi, D;Maestri, R;Bordi, C
工作背景：本研究的目的是评价心室心外膜脂肪的范围及其与基础心肌的关系，这两者都还没有完全了解。研究方法：将117例尸检心脏分为正常组（N）、缺血组（I）、肥厚组（H）和肥厚缺血组（HI）。在每个心脏中，测量心室心肌和心外膜脂肪重量。根据这些数据，计算心室内的心外膜脂肪百分比。结果：左心室、右心室和总心室脂肪重量在H组和HI组均大于N组和I组（分别为P <0.05，P <0.05，P <0.01）。在比较H与HI和N与I时，未检测到心外膜脂肪重量存在差异。此外，四组之间每个心室中的脂肪百分比没有变化。然而，如果与右心室相比，左心室显示心外膜脂肪百分比始终较低（P < .0001）。在非肥厚心脏（N和I）中，体重指数和心外膜脂肪总重量相关（P <0.05），而在肥厚心脏（H和HI）中，它们不相关。结论：各心室存在恒定的脂肪-肌肉比，不受缺血的影响。或肥大。因此，在肥厚过程中，心室脂肪和下面的心肌显示出平行和相关的质量增加。(C)2004年爱思唯尔公司All rights reserved.
Background: The purpose of the present study was to evaluate the extent of the ventricular epicardial fat and its relationship with the underlying myocardium, neither of which is still completely understood. Methods: A total of 117 autoptic human hearts was subdivided into four groups: normals (N), ischemics (I), hypertrophics (H) and hypertrophic-ischemics (HI). In each heart, the ventricular myocardial and epicardial fat weights were measured. On the basis of these data, the epicardial fat percentage within the ventricles was calculated. Results: The left, right and total ventricular fat weights were greater in H and HI than in N and I (P < .05, P < .05, P < .01, respectively). No differences were detected in the epicardial fat weights in comparing H versus HI and N versus I. Moreover, the fat percentage in each ventricle did not vary between the four groups. However, if compared with the right ventricle, the left ventricle showed an epicardial fat percentage consistently lower (P < .0001). In nonhypertrophied hearts (N and I), the body mass index and the total epicardial fat weight were correlated (P < .05), whereas in hypertrophied hearts (H and HI), they were not. Conclusions: A constant fat-muscle ratio exists in each ventricle, which is not influenced by ischemia. or hypertrophy. Accordingly, during the hypertrophic process, the ventricular fat and the underlying myocardium show a parallel and correlated increase in their masses. (C) 2004 Elsevier Inc. All rights reserved.