Abdominal and gluteofemoral size and risk of liver cancer: The liver cancer pooling project
Abdominal and gluteofemoral size and risk of liver cancer: The liver cancer pooling project
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DOI：
10.1002/ijc.32760
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发表时间：
2019-12-23
影响因子：
6.4
通讯作者：
Petrick, Jessica L.
中科院分区：
文献类型：
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作者：
Florio, Andrea A.;Campbell, Peter T.;Petrick, Jessica L.
肥胖已知与原发性肝癌（PLC）有关，但腹部和臀股体积过大的单独影响尚不清楚。因此，我们研究了腰围和臀围与PLC总体风险和组织学类型（肝细胞癌（HCC）和肝内胆管癌（ICC））之间的关系。肝癌汇集项目是一个前瞻性队列研究联盟，包括来自1,167,244名个体的数据（PLC n = 2,208, HCC n = 1,154, ICC n = 335）。采用比例风险回归估计多变量校正风险比（hr）和95%置信区间（CI）。腰围，每增加5厘米，与PLC风险增加11%相关（HR = 1.11, 95%CI: 1.09-1.14），包括调整臀围（HR = 1.12, 95%CI: 1.08-1.17）以及限制在正常体重指数（BMI）范围内的个体（18.5 -1.17）
Obesity is known to be associated with primary liver cancer (PLC), but the separate effects of excess abdominal and gluteofemoral size are unclear. Thus, we examined the association between waist and hip circumference with risk of PLC overall and by histologic type-hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). The Liver Cancer Pooling Project is a consortium of prospective cohort studies that include data from 1,167,244 individuals (PLC n = 2,208, HCC n = 1,154, ICC n = 335). Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CI) were estimated using proportional hazards regression. Waist circumference, per 5 cm increase, was associated with an 11% increased PLC risk (HR = 1.11, 95%CI: 1.09-1.14), including when adjusted for hip circumference (HR = 1.12, 95%CI: 1.08-1.17) and also when restricted to individuals in a normal body mass index (BMI) range (18.5 to