USE OF DIRECT-CURRENT TO CAUSE SELECTIVE BLOCK OF LARGE FIBERS IN PERIPHERAL-NERVES
USE OF DIRECT-CURRENT TO CAUSE SELECTIVE BLOCK OF LARGE FIBERS IN PERIPHERAL-NERVES
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DOI：
10.1093/bja/47.11.1123-b
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发表时间：
1975-01-01
影响因子：
9.8
通讯作者：
KIDD, C
中科院分区：
文献类型：
--
作者：
WHITWAM, JG;KIDD, C
本文研究了直流电对狗桡神经皮分支传播复合动作电位的影响，并介绍了一种简便的神经通电方法。阻断电流的变化，即使是在5-10秒的时间内缓慢进行，也会刺激神经。该方法在有髓纤维内产生差异性神经阻滞不令人满意。结果证实，直流电可用于选择性消除II/III族电位。当这些电位已被消除了一段时间的5分钟，组IV电位的平均高度降低到65%的控制值，其传导速度降低了10%。电流的相对小的变化引起传导的显著变化。在早期阶段的块，经常相对较大的减少电流流量是必要的，以产生一个恒定的响应，它是不可能的，直到阻断电流已被施加至少1分钟，以引起一个稳定的效果传导。由于神经损伤的方法是不适合临床使用。
The effect of direct current on the propagated compound action potential in a cutaneous branch of the radial nerve of the dog was studied and a convenient method for applying electrical current to a nerve is described. Changes in the flow of blocking current, even when these were made slowly during a period of 5–10 sec, caused stimulation of the nerve. The method was unsatisfactory for producing differential nerve block within the myelinated fibres. It was confirmed that direct current could be used to eliminate selectively the group II/III potentials. When these potentials had been eliminated for a period of 5 min the mean height of the group IV potentials was reduced to 65% of the control value, and their conduction velocity was decreased by 10%. Relatively small variations in current flow caused a marked change in conduction. In the early stages of block, frequent relatively large reductions in current flow were necessary to produce a constant response and it was impossible to cause a stable effect on conduction until the blocking current had been applied for at least 1 min. Because of nerve damage the method is unsuitable for clinical use.