Intracellular signalling proteins as 'smart' agents in parallel distributed processes
Intracellular signalling proteins as 'smart' agents in parallel distributed processes
复制标题
DOI：
10.1016/s0303-2647(99)00006-4
复制
发表时间：
1999-06-01
期刊：
影响因子：
1.6
通讯作者：
Matsuno, K
中科院分区：
文献类型：
--
作者：
Fisher, MJ;Paton, RC;Matsuno, K
在真核生物中，对外界信号的反应是由一系列细胞内信号通路介导的，最终导致蛋白激酶和/或蛋白磷酸酶的激活/失活。直到最近，很少有人考虑这些信号通路的成分在细胞内的分布。然而，来自不同生物体的实验证据表明，信号级联的许多蛋白质成分并不是自由分布的，而是表现出很大程度的空间组织。在这里，我们简要回顾了‘锚’，‘支架’和‘适配器’蛋白在细胞内信号通路的组织和功能中的作用。然后，我们考虑了这些自适应系统的一些并行分布式处理能力。我们专注于信号蛋白质--既作为独立的‘设备’(代理)，也作为并行过程的‘网络’(生态)，信号蛋白质被描述为‘智能热力学机器’，在细胞的信息经济中满足‘粘合’(功能)的角色。这结合了信号蛋白质的两种信息处理观点。在个体上，它们表现出“认知”能力，并共同整合(连贯地)细胞过程。我们通过比较信号蛋白和动词来利用这些观点。这种文本/对话隐喻也有助于完善我们对信号蛋白质作为上下文敏感信息处理剂的看法。(C)1999爱思唯尔爱尔兰科学有限公司。保留所有权利。
In eucaryotic organisms, responses to external signals are mediated by a repertoire of intracellular signalling pathways that ultimately bring about the activation/inactivation of protein kinases and/or protein phosphatases. Until relatively recently, little thought had been given to the intracellular distribution of the components of these signalling pathways. However, experimental evidence from a diverse range of organisms indicates that rather than being freely distributed, many of the protein components of signalling cascades show a significant degree of spatial organisation. Here, we briefly review the roles of 'anchor', 'scaffold' and 'adaptor' proteins in the organisation and functioning of intracellular signalling pathways. We then consider some of the parallel distributed processing capacities of these adaptive systems. We focus on signalling proteins-both as individual 'devices' (agents) and as 'networks' (ecologies) of parallel processes, signalling proteins are described as 'smart thermodynamic machines' which satisfy 'gluing' (funetorial) roles in the information economy of the cell. This combines two information-processing views of signalling proteins. Individually, they show 'cognitive' capacities and collectively they integrate (cohere) cellular processes. We exploit these views by drawing comparisons between signalling proteins and verbs. This text/dialogical metaphor also helps refine our view of signalling proteins as context-sensitive information processing agents. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.