Executive "brake failure" following deactivation of human frontal lobe
Executive "brake failure" following deactivation of human frontal lobe
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DOI：
10.1162/jocn.2006.18.3.444
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发表时间：
2006-03-01
影响因子：
3.2
通讯作者：
Mattingley, JB
中科院分区：
文献类型：
--
作者：
Chambers, CD;Bellgrove, MA;Mattingley, JB
在日常生活中，人类经常会遇到这样的情况：一旦启动一项运动行为，它就变得不必要或不恰当。在这种情况下，抑制运动反应的能力可能至关重要。尽管反应抑制的本质在心理学领域已经被研究了几十年，但其神经基础仍然不清楚。通过经颅磁刺激，我们发现右侧额下回的岛盖部暂时失活会选择性地损害停止已启动动作的能力。关键的是，同一区域的失活既不影响执行反应的能力，也不影响生理唤醒。这些发现证实并扩展了近期的报告，即额下回对于介导反应抑制至关重要。
in the course of daily living, humans frequently encounter situations in which a motor activity, once initiated, becomes unnecessary or inappropriate. Under such circumstances, the ability to inhibit motor responses can be of vital importance. Although the nature of response inhibition has been studied in psychology for several decades, its neural basis remains unclear. Using transcranial magnetic stimulation, we found that temporary deactivation of the pars opercularis in the right inferior frontal gyrus selectively impairs the ability to stop an initiated action. Critically, deactivation of the same region did not affect the ability to execute responses, nor did it influence physiological arousal. These findings confirm and extend recent reports that the inferior frontal gyrus is vital for mediating response inhibition.