Super agonist actions of clothianidin and related compounds on the SADβ2 nicotinic acetylcholine receptor expressed in Xenopus laevis oocytes
Super agonist actions of clothianidin and related compounds on the SADβ2 nicotinic acetylcholine receptor expressed in Xenopus laevis oocytes
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DOI：
10.1271/bbb.68.761
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发表时间：
2004-03-01
影响因子：
1.6
通讯作者：
Komai, K
中科院分区：
文献类型：
--
作者：
Ihara, M;Matsuda, K;Komai, K
为了比较噻虫胺（一种作用于昆虫烟碱乙酰胆碱受体的类烟碱化合物）和相关化合物与吡虫啉的作用，使用双电极电压钳电生理学对在非洲爪蟾卵母细胞中表达的果蝇SAD-鸡β 2烟碱乙酰胆碱受体测试化合物。SAD β 2烟碱受体对噻虫胺的最大反应大于乙酰胆碱。吡虫啉的咪唑烷环的环断裂导致胍基的产生是这种超级激动剂作用的关键。
To compare the actions of clothianidin, a neonicotinoid acting on insect nicotinic acetylcholine receptors, and related compounds with that of imidacloprid, the compounds were tested on the Drosophila SAD-chicken beta2 nicotinic acetylcholine receptor expressed in Xenopus laevis oocytes using two-electrode voltage-clamp electrophysiology. The maximum response of the SADbeta2 nicotinic receptor to clothianidin was larger than that observed for acetylcholine. Ring breakage of the imidazolidine ring of imidacloprid resulting in the generation of a guanidine group was critical for this super agonist action.