Metabolic reprogramming in triple-negative breast cancer
Metabolic reprogramming in triple-negative breast cancer
复制标题
DOI：
10.20892/j.issn.2095-3941.2019.0210
复制
发表时间：
2020
影响因子：
5.5
通讯作者：
Dong Chenfang
中科院分区：
文献类型：
--
作者：
Wang Zhanyu;Jiang Qianjin;Dong Chenfang
Since triple-negative breast cancer (TNBC)was first defined over a decade ago,increasing studies have focused on its genetic and molecular characteristics.Patients diagnosed with TNBC,compared to those diagnosed with other breast cancer subtypes,have relatively poor outcomes due to high tumor aggressiveness and lack of targeted treatment.Metabolic reprogramming,an emerging hallmark of cancer,is hijacked by TNBC to fulfill bioenergetic and biosynthetic demands;maintain the redox balance;and further promote oncogenic signaling,cell proliferation,and metastasis.Understanding the mechanisms of metabolic remodeling may guide the design of metabolic strategies for the effective intervention of TNBC.Here,we review the metabolic reprogramming of glycolysis,oxidative phosphorylation,amino acid metabolism,lipid metabolism,and other branched pathways in TNBC and explore opportunities for new biomarkers,imaging modalities,and metabolically targeted therapies.
