Volumetric computed tomography with carbon nanotube X-ray source array for improved image quality and accuracy.
Volumetric computed tomography with carbon nanotube X-ray source array for improved image quality and accuracy.
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采用碳纳米管 X 射线源阵列的体积计算机断层扫描可提高图像质量和准确性。
DOI：
10.1038/s44172-023-00123-x
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Zhou,Otto
中科院分区：
文献类型：
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作者：
Xu,Shuang;Hu,Yuanming;Li,Boyuan;Inscoe,ChristinaR;Tyndall,DonaldA;Lee,YuehZ;Lu,Jianping;Zhou,Otto
锥形束计算机断层扫描（CBCT）广泛应用于医学和牙科成像。与多探测器CT相比，它提供了具有高各向同性分辨率的体积图像，同时降低了辐射剂量、成本和占地面积，而无需患者平移。目前的CBCT有几个固有的局限性，包括软组织对比度降低，X射线衰减的不准确量化，图像失真和伪影，这限制了其主要用于成像硬组织的临床应用，并使定量分析具有挑战性。在这里，我们报告了一种多束CBCT（ms-CBCT），它克服了传统CBCT的缺点，通过使用多个窄准直和快速扫描的X射线束从碳纳米管场发射源阵列。体模成像研究表明，与CBCT配置相比，ms-CBCT将Hounsfield单位值的准确性提高了60%，消除了锥形束伪影，扩展了轴向覆盖范围，并将软组织对比度噪声比提高了30- 50%。
Cone beam computed tomography (CBCT) is widely used in medical and dental imaging. Compared to a multidetector CT, it provides volumetric images with high isotropic resolution at a reduced radiation dose, cost and footprint without the need for patient translation. The current CBCT has several intrinsic limitations including reduced soft tissue contrast, inaccurate quantification of X-ray attenuation, image distortions and artefacts, which have limited its clinical applications primarily to imaging hard tissues and made quantitative analysis challenging. Here we report a multisource CBCT (ms-CBCT) which overcomes the shortcomings of the conventional CBCT by using multiple narrowly collimated and rapidly scanning X-ray beams from a carbon nanotube field emission source array. Phantom imaging studies show that, the ms-CBCT increases the accuracy of the Hounsfield unit values by 60%, eliminates the cone beam artefacts, extends the axial coverage, and improves the soft tissue contrast-to-noise ratio by 30–50%, compared to the CBCT configuration.