Genotype Distributions and Allele Frequencies of Possible Major Depressive Disorder-Associated Single Nucleotide Polymorphisms,. Cyclic Adenosine Monophosphate Response Element Binding Protein 1 rs4675690 and Piccolo rs2522833, in a Japanese Population
Genotype Distributions and Allele Frequencies of Possible Major Depressive Disorder-Associated Single Nucleotide Polymorphisms,. Cyclic Adenosine Monophosphate Response Element Binding Protein 1 rs4675690 and Piccolo rs2522833, in a Japanese Population
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DOI：
10.1248/bpb.35.265
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发表时间：
2012-02-01
影响因子：
2
通讯作者：
Itoh, Kunihiko
中科院分区：
文献类型：
--
作者：
Inoue, Kazuyuki;Ando, Natsuko;Itoh, Kunihiko
抑郁症的发病与遗传因素有关。调查精神疾病的易感性，如MDD、精神分裂症等，有必要比较患者与对照组客观多态性的遗传差异。近年来，越来越多的研究关注环磷酸腺苷反应元件结合蛋白I（CREB 1）和Piccolo（PCLO）在MDD中的作用。然而，目前还没有关于日本人群中MDD患者和健康受试者之间多态性遗传特征的报道。我们分析了267名日本受试者CREB 1 rs4675690和PCLO rs2522833多态性的基因型分布和等位基因频率。CREB 1 rs4675690中C等位基因频率（0.41）低于T等位基因频率（0.59）。PCLO rs2522833中A等位基因频率（0.45）低于C等位基因频率（0.55）。我们的研究结果可能是有用的调查遗传因素的易感性MDD在日本人口。
It is known that the onset of major depressive disorder (MDD) would be associated with genetic factors. To investigate the susceptibility to psychiatric disorders, e.g. MDD, schizophrenia etc., it is necessary to compare the genetic differences of objective polymorphisms between in patients and in relative contol subjects. Recently, an increasing number of studies focused on the role of cyclic adenosine monophosphate response element binding protein I (CREB1) and Piccolo (PCLO) on MDD. However, there was no report about genetic characterization of polymorphisms in between MDD patients and healthy subjects in Japanese population. We analized genotype distributions and allele frequencies of CREB1 rs4675690 and PCLO rs2522833 polymorphisms in 267 Japanese subjects, respectively. In CREB1 rs4675690, C allele frequency (0.41) was lower than T allele (0.59). While in PCLO rs2522833, A allele frequency (0.45) was lower than C allele (0.55). Our findings may be useful for investigating the genetic factors concerning the susceptibility to MDD in Japanese population.