Clozapine and the Dopamine Hypothesis of Schizophrenia, a Critical Appraisal
Clozapine and the Dopamine Hypothesis of Schizophrenia, a Critical Appraisal
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氯氮平和精神分裂症的多巴胺假说，一个批判性的评估
DOI：
10.1055/s-0028-1094449
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
White Tg
中科院分区：
文献类型：
--
作者：
Bürki Hr;E. Eichenberger;Sayers Ac;White Tg
本文讨论了氯氮平的一些药理学和神经化学性质，以及氯氮平区别于经典抗精神病药的特殊属性。关于氯氮平是否阻断DA受体的问题--精神分裂症多巴胺假说的一个关键点--受到了特别的关注。神经化学，神经药理学和内分泌学的证据，反对DA-受体阻滞剂氯氮平的相关剂量。这些发现很难与多巴胺假说相一致，该假说提出抗精神病作用与DA受体阻滞之间存在直接关系。
This paper discusses some of the pharmacological and neurochemical properties of clozapine, and the special attributes that differentiate clozapine from the classical neuroleptics. The question as to whether or not clozapine blocks DA-receptors--a crucial point in regard to the dopamine hypothesis of schizophrenia--has received particular attention. Neurochemical, neuropharmacological, and endocrinological evidence is presented which speaks against a DA-receptor blockade by clozapine in pharmacologically relevant doses. These findings are difficult to reconcile with the dopamine hypothesis which proposes a direct relationship between antipsychotic effect and DA-receptor blockade.