The glycosylation stoichiometry of EWS species in neuronal cells

The glycosylation stoichiometry of EWS species in neuronal cells
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神经元细胞中 EWS 物种的糖基化化学计量

DOI：
10.1080/09168451.2016.1230004
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发表时间：
2017
期刊：
Bioscience, Biotechnology, and Biochemistry
影响因子：
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通讯作者：
Kazuo Kamemura and Hiromi Abe
Kazuo Kamemura and Hiromi Abe
中科院分区：
--
文献类型：
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作者：
Nomura;K.;Tanimoto;Y.;Hayashi;F.;Harada;E.;Shan;X.-Y.;Shionyu;M.;Hijikata;A.;Shirai;T.;Morigaki;K.;Shimamoto;K.;Kazuo Kamemura and Hiromi Abe

文献摘要

相似文献

虽然尤文肉瘤蛋白（EWS）被O-连接的β-N-乙酰葡萄糖胺（O-GlcNAc）糖基化，但其糖基化的动力学和化学计量学仍不清楚。在这里，我们报告了胚胎癌P19细胞神经元分化过程中EWS种类糖基化化学计量的动态变化。我们的研究结果表明O-GlcNAc糖基化参与了神经细胞EWS功能的调节。
Although Ewing sarcoma protein (EWS) is known to be glycosylated byO-linked β-N-acetylglucosamine (O-GlcNAc), the dynamics and stoichiometry of its glycosylation remain obscure. Here, we report a dynamic change in the glycosylation stoichiometry of EWS species during neuronal differentiation of embryonic carcinoma P19 cells. Our findings suggest thatO-GlcNAc glycosylation participates in the regulation of EWS functions in neuronal cells.