The SIDER database of drugs and side effects.
The SIDER database of drugs and side effects.
复制标题
药物和副作用的SIDER数据库。
DOI：
10.1093/nar/gkv1075
复制
发表时间：
2016-01-04
影响因子：
14.9
通讯作者：
Bork P
中科院分区：
文献类型：
--
作者：
Kuhn M;Letunic I;Jensen LJ;Bork P
药物的不良副作用是患者的负担，也是新药开发的严重障碍。同时，临床试验期间记录的药物不良反应（ADR）是人类表型数据的重要来源。因此，有必要将药物、靶标和副作用的数据结合起来，更全面地了解药物的治疗机制及其引起不良反应的方式。为此，我们创建了药物和 ADR 的 SIDER（“副作用资源”，http://sideeffects.embl.de）数据库。当前版本 SIDER 4 包含 1430 种药物、5880 个 ADR 和 140064 个药物 - ADR 对的数据，与之前的版本相比增加了 40%。为了进行更细粒度的分析，我们从包装说明书中提取了副作用发生的频率。该信息适用于 39% 的药物 - ADR 对，其中 19% 可以与安慰剂治疗下的频率进行比较。 SIDER还包含使用自然语言处理从包装说明书中提取的药物适应症数据集。这些药物适应症用于通过识别与 ADR 不对应的医学术语来降低误报率。
Unwanted side effects of drugs are a burden on patients and a severe impediment in the development of new drugs. At the same time, adverse drug reactions (ADRs) recorded during clinical trials are an important source of human phenotypic data. It is therefore essential to combine data on drugs, targets and side effects into a more complete picture of the therapeutic mechanism of actions of drugs and the ways in which they cause adverse reactions. To this end, we have created the SIDER (‘Side Effect Resource’, http://sideeffects.embl.de) database of drugs and ADRs. The current release, SIDER 4, contains data on 1430 drugs, 5880 ADRs and 140 064 drug–ADR pairs, which is an increase of 40% compared to the previous version. For more fine-grained analyses, we extracted the frequency with which side effects occur from the package inserts. This information is available for 39% of drug–ADR pairs, 19% of which can be compared to the frequency under placebo treatment. SIDER furthermore contains a data set of drug indications, extracted from the package inserts using Natural Language Processing. These drug indications are used to reduce the rate of false positives by identifying medical terms that do not correspond to ADRs.