Association between the DRD2-141C Insertion/Deletion polymorphism and schizophrenia
Association between the DRD2-141C Insertion/Deletion polymorphism and schizophrenia
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DOI：
10.1590/s0004-282x2009000200004
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发表时间：
2009-06-01
影响因子：
1.4
通讯作者：
Vallada, Homero
中科院分区：
文献类型：
--
作者：
Cordeiro, Quirino;Siqueira-Roberto, Jacqueline;Vallada, Homero
流行病学研究表明，遗传因素是精神分裂症发生的重要危险因素。编码多巴胺能系统不同化合物的基因引起了精神分裂症患者分子研究的兴趣，因为抗精神病药物，特别是第一代抗精神病药物，作用于这个大脑系统。因此，本研究的目的是调查多巴胺受体2型（DRD 2）-141 Ins/Del（rs 1799732）多态性与精神分裂症之间的可能关联。在229名患者和733名对照样本中研究了所研究的多态性的等位基因和基因型的分布。患者和对照组之间的等位基因（chi 2=9.78; p=0.001）和基因型（chi（2）=12.74; p=0.001）分布存在统计学差异。因此，DRD 2基因的-141C Ins/Del多态性（等位基因Ins）与所研究样本中的SCZ表型相关。
Epidemiological studies have demonstrated that the genetic component is an important risk factor for the development of schizophrenia. The genes that codify the different compounds of the dopaminergic system have created interest for molecular investigations in patients with schizophrenia because the antipsychotic drugs, especially those of first generation, act on this cerebral system. Thus the aim of the present study was to investigate the possible association between the -141 Ins/Del (rs1799732) polymorphism of the dopamine receptor type 2 (DRD2) and schizophrenia. The distribution of the alleles and genotypes of the studied polymorphism was investigated in a sample of 229 patients and 733 controls. There were statistical differences in the allelic (chi 2=9.78; p=0.001) and genotypic genotypic (chi(2)=12.74; p=0.001) distributions between patients and controls. Thus the -141C Ins/Del polymorphism of the DRD2 gene (allele Ins) was associated to the SCZ phenotype in the investigated sample.