The Potential Role of Platelet-Related microRNAs in the Development of Cardiovascular Events in High-Risk Populations, Including Diabetic Patients: A Review.
The Potential Role of Platelet-Related microRNAs in the Development of Cardiovascular Events in High-Risk Populations, Including Diabetic Patients: A Review.
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DOI：
10.3389/fendo.2018.00074
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发表时间：
2018
影响因子：
5.2
通讯作者：
Postula M
中科院分区：
文献类型：
--
作者：
Pordzik J;Pisarz K;De Rosa S;Jones AD;Eyileten C;Indolfi C;Malek L;Postula M
血小板活化在动脉粥样硬化的发展和进展中起着关键作用，这通常导致疾病后期的潜在致命性缺血事件。血小板和血小板微泡（PMV）含有大量的microRNA（miRNA），其在很大程度上贡献于循环miRNA库。因此，它们代表了开发创新诊断生物标志物的有希望的选择，该生物标志物可以特异于潜在病因。循环中的miRNA可以负责细胞内通讯，并且可以对靶细胞具有生物学效应。由于与心血管疾病（CVD）和糖尿病相关的miRNA可以通过多种技术进行测量，因此它们可以被开发为一类创新的智能疾病生物标志物。在本文中，我们提供了与血小板功能和反应性相关的miRNA（miR-223，miR-126，miR-197，miR-191，miR-21，miR-150，miR-155，miR-140，miR-96，miR-98）的概述，这些miRNA应作为新的生物标志物进行评估，以改善CVD的诊断和治疗。
Platelet activation plays a pivotal role in the development and progression of atherosclerosis, which often leads to potentially fatal ischemic events at later stages of the disease. Platelets and platelet microvesicles (PMVs) contain large amounts of microRNA (miRNA), which contributes largely to the pool of circulating miRNAs. Hence, they represent a promising option for the development of innovative diagnostic biomarkers, that can be specific for the underlying etiology. Circulating miRNAs can be responsible for intracellular communication and may have a biological effect on target cells. As miRNAs associated to both cardiovascular diseases (CVD) and diabetes mellitus can be measured by means of a wide array of techniques, they can be exploited as an innovative class of smart disease biomarkers. In this manuscript, we provide an outline of miRNAs associated with platelet function and reactivity (miR-223, miR-126, miR-197, miR-191, miR-21, miR-150, miR-155, miR-140, miR-96, miR-98) that should be evaluated as novel biomarkers to improve diagnostics and treatment of CVD.