Social-economic costs and quality of life of Alzheimer disease in the Canary Islands, Spain
Social-economic costs and quality of life of Alzheimer disease in the Canary Islands, Spain
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DOI：
10.1212/01.wnl.0000249311.80411.93
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发表时间：
2006-12-26
期刊：
影响因子：
9.9
通讯作者：
Oliva-Moreno, Juan
中科院分区：
文献类型：
--
作者：
Lopez-Bastida, Julio;Serrano-Aguilar, Pedro;Oliva-Moreno, Juan
目的：研究2001年西班牙加那利群岛阿尔茨海默病（AD）的经济负担（直接和间接费用），并分析其对AD患者和护理人员健康相关生活质量（HRQOL）的影响。方法：从加那利群岛的阿尔茨海默病协会招募了237例患者（占接触者的61%）。人口统计学，卫生资源利用，非正式护理，间接成本和生活质量的数据收集从患者的主要照顾者作为代理受访者。使用通用问卷EQ-5D测量患者和护理人员的HRQOL。结果：每位AD患者的平均年费用为28，198欧元（36，144美元）。最重要的费用类别是非正式护理和药品。认知障碍的费用也随之增加，轻度患者的年平均费用为14，956欧元（19，171美元），中度患者为25，562欧元（32，765美元），重度患者为41，669欧元（53，411美元）。加那利群岛AD患者的总费用为2.59亿欧元（3.32亿美元）。采用EQ-5D社交量表的HRQOL为0.29（患者）和0.67（护理人员）。患者的EQ-5D VAS（温度计）评分为42分，护理人员为62分。结论：AD的直接医疗保健费用占加那利群岛公共医疗保健总支出的2.4%。在所有严重程度水平中，我们估计西班牙65岁以上AD患者的年总成本为100亿欧元（130亿美元）。AD患者的严重程度显著影响患者的生活质量，但不影响照顾者的生活质量。
Objectives: To examine the economic burden (direct and indirect costs) of Alzheimer disease (AD) and to analyze the impact on health-related quality of life (HRQOL) for patients with AD and caregivers in 2001 in the Canary Islands, Spain. Methods: Two hundred thirty-seven patients (61% of those contacted) were recruited from the Alzheimer's Disease Association in the Canary Islands. Demographic, health resources utilization, informal care, indirect costs, and quality of life data were collected from primary caregivers of patients as proxy respondents. HRQOL was measured for patients and caregivers with the generic questionnaire EQ-5D. Results: The average annual cost per patient with AD was EURO28,198 (US $36,144). The most important categories of costs were for informal care and drugs. Costs increased with cognitive impairment with an average annual cost of EURO14,956 (US $ 19,171) for mild, EURO25,562 (US $ 32,765) for moderate, and EURO41,669 (US $ 53,411) for severe patients. The total cost of patients with AD in Canary Islands was EURO259 (US $ 332) million. The HRQOL with the EQ-5D social tariff was 0.29 for patients and 0.67 for caregivers. The EQ-5D VAS (thermometer) score was 42 for patients and 62 for caregivers. Conclusions: Direct health care costs of AD represented 2.4% of the total public health care expenditure in the Canary Islands. Across all severity levels, we estimated a total annual cost of EURO10 (US $ 13) billion for AD patients older than 65 years in Spain. The degree of severity of the patients with AD substantially influenced the quality of life of the patients but not that of the caregivers.