GABAB receptor in the antihypersensitive effect in anterior cingulate cortex of partial sciatic nerve ligation model
GABAB receptor in the antihypersensitive effect in anterior cingulate cortex of partial sciatic nerve ligation model
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GABAB受体在坐骨神经部分结扎模型前扣带皮层抗过敏作用中的作用
DOI：
10.1016/j.jphs.2018.05.009
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Honda K
中科院分区：
文献类型：
--
作者：
Migita K;Matsuzaki Y;Koga K;Matsumoto T;Mishima K;Hara S;Honda K
GABA受体在前扣带皮层（ACC）神经病理性疼痛中的作用尚不清楚。向ACC注射GABAB受体拮抗剂CGP 35348可诱导正常大鼠机械性超敏反应。在部分坐骨神经结扎（PSNL）大鼠中，将GABA B受体激动剂巴氯芬注射到ACC中激活GABA B受体可减轻机械超敏反应。在PSNL大鼠ACC内共注射CGP 35348和M1受体激动剂McN-A-343可显著抑制McN-A-343诱导的抗过敏反应。这些结果表明，ACC中的GABA B受体有助于机械超敏反应，并参与了毒蕈碱M1受体介导的抗超敏反应。
The role of the GABABreceptor in the anterior cingulate cortex (ACC) of neuropathic pain is unclear. Injection of a GABABreceptor antagonist CGP35348 into the ACC induced mechanical hypersensitivity in normal rats. Activation of the GABABreceptor injected by a GABABreceptor agonist baclofen into the ACC attenuated mechanical hypersensitivity in partial sciatic nerve ligation (PSNL) rats. Co-microinjection of CGP35348 with a muscarinic M1 receptor agonist McN-A-343 into the ACC significantly inhibited McN-A-343-induced antihypersensitivity in PSNL rats. These results suggest that the GABABreceptor in the ACC contributes to mechanical hypersensitivity and is involved in muscarinic M1receptor-mediated antihypersensitivity.