SARS-CoV-2 infection in patients on renal replacement therapy. Report of the COVID-19 Registry of the Spanish Society of Nephrology (SEN)
SARS-CoV-2 infection in patients on renal replacement therapy. Report of the COVID-19 Registry of the Spanish Society of Nephrology (SEN)
复制标题
DOI：
10.1016/j.nefro.2020.04.002
复制
发表时间：
2020-05-01
期刊：
影响因子：
2.6
通讯作者：
del Pino y Pino, Maria Dolores
中科院分区：
文献类型：
--
作者：
Emilio Sanchez-Alvarez, J.;Perez Fontan, Miguel;del Pino y Pino, Maria Dolores
简介：最近出现的 SARS-CoV-2 冠状病毒大流行对普通人群产生了重大影响。接受肾脏替代治疗（RRT）的患者并非没有意识到这种情况，并且由于他们的特点，他们特别容易受到伤害。我们展示了西班牙肾脏病学会 COVID-19 登记处的分析结果。材料和方法：该登记处于 2020 年 3 月 18 日开始运营。它收集流行病学变量、传染和诊断数据、体征和症状、治疗和结果。它是一个在线注册表。患者根据病毒 PCR 的结果被诊断为 SARS-CoV-2 感染，对表现出相容症状或可疑体征的患者以及与另一名患者有一定接触后接受筛查的患者进行了 PCR 检测。结果：截至 4 月 11 日，登记处拥有来自所有自治区的 868 名患者的数据。 RRT 最具代表性的形式是中心血液透析 (ICH)，其次是移植患者。症状与一般人群相似。非常高的比例 (85%) 需要入院，其中 8% 需要住院治疗。最常用的治疗方法是羟氯喹、洛匹那韦-利托那韦和类固醇。死亡率很高，达到23%；已故患者更频繁地出现脑出血，更频繁地出现肺炎，并且更少接受洛匹那韦-利托那韦和类固醇治疗。年龄和肺炎与死亡风险独立相关。结论：SARS-CoV-2感染已经影响了大量接受RRT的西班牙患者，主要是那些接受ICH的患者，住院率非常高，死亡率也很高；年龄和肺炎的发展是与死亡率相关的因素。 (C) 2020 Sociedad Espanola de Nefrologia。由 Elsevier Espana, S.L.U. 出版
Introduction: The recent appearance of the SARS-CoV-2 coronavirus pandemic has had a significant impact on the general population. Patients on renal replacement therapy (RRT) have not been unaware of this situation and due to their characteristics they are especially vulnerable. We present the results of the analysis of the COVID-19 Registry of the Spanish Society of Nephrology.Material and methods: The Registry began operating on March 18th, 2020. It collects epidemiological variables, contagion and diagnosis data, signs and symptoms, treatments and outcomes. It is an online registry. Patients were diagnosed with SARS-CoV-2 infection based on the results of the PCR of the virus, carried out both in patients who had manifested compatible symptoms or had suspicious signs, as well as in those who had undergone screening after some contact acquainted with another patient.Results: As of April 11, the Registry had data on 868 patients, from all the Autonomous Communities. The most represented form of RRT is in-center hemodialysis (ICH) followed by transplant patients. Symptoms are similar to the general population. A very high percentage (85%) required hospital admission, 8% in intensive care units. The most used treatments were hydroxychloroquine, lopinavir-ritonavir, and steroids. Mortality is high and reaches 23%; deceased patients were more frequently on ICH, developed pneumonia more frequently, and received less frequently lopinavir-ritonavir and steroids. Age and pneumonia were independently associated with the risk of death.Conclusions: SARS-CoV-2 infection already affects a significant number of Spanish patients on RRT, mainly those on ICH, hospitalization rates are very high and mortality is high; age and the development of pneumonia are factors associated with mortality. (C) 2020 Sociedad Espanola de Nefrologia. Published by Elsevier Espana, S.L.U.