Long-Range Clustered Connections within Extrastriate Visual Area V5/MT of the Rhesus Macaque
Long-Range Clustered Connections within Extrastriate Visual Area V5/MT of the Rhesus Macaque
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DOI：
10.1093/cercor/bhr072
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发表时间：
2012-01-01
期刊：
影响因子：
3.7
通讯作者：
Krug, Kristine
中科院分区：
文献类型：
--
作者：
Ahmed, Bashir;Cordery, Patricia M.;Krug, Kristine
恒河猴的视觉区V5/MT具有独特的功能组织，其中对运动方向和双眼视差具有特定偏好的神经元共同组织在列或簇中。在这里，我们分析了模式的内在连接皮质区V5/MT在两个parasocellular部分的完整的大脑和切向部分从flatmounted皮质逆行示踪剂霍乱毒素亚基B小注射。标记的细胞主要发现在皮质层2，3，和6。沿着皮质层沿着，标记的细胞集中在规则间隔的簇中。最靠近注射部位的簇距其中心约2 mm。在平铺的皮质中，沿着V5/MT的背腹轴，我们进一步鉴定了距离注射部位10 mm的标记细胞簇。对骨旁切片的定量分析估计平均簇间距为2.2 mm;在皮质平片中，从注射部位径向测量的间距为2.3 mm。结果表明，V5/MT内的内在连接的规则模式，这是一致的网站之间的连接与一个共同的偏好运动的方向和双目深度。这种长距离连接可能是V5/MT神经元周围存在大量抑制性神经元的原因。
Visual area V5/MT in the rhesus macaque has a distinct functional organization, where neurons with specific preferences for direction of motion and binocular disparity are co-organized in columns or clusters. Here, we analyze the pattern of intrinsic connectivity within cortical area V5/MT in both parasagittal sections of the intact brain and tangential sections from flatmounted cortex using small injections of the retrograde tracer cholera toxin subunit b. Labeled cells were predominantly found in cortical layers 2, 3, and 6. Going along the cortical layers, labeled cells were concentrated in regularly spaced clusters. The clusters nearest to the injection site were approximately 2 mm from its center. In flatmounted cortex, along the dorsoventral axis of V5/MT, we identified further clusters of labeled cells up to 10 mm from the injection site. Quantitative analysis of parasagittal sections estimated average cluster spacing at 2.2 mm; in cortical flatmounts, spacing was 2.3 mm measured radially from the injection site. The results suggest a regular pattern of intrinsic connectivity within V5/MT, which is consistent with connectivity between sites with a common preference for both direction of motion and binocular depth. The long-range connections can potentially account for the large suppressive surrounds of V5/MT neurons.