Combining functional scales and cognitive tests in screening for mild cognitive impairment at a university-based memory clinic in Brazil
Combining functional scales and cognitive tests in screening for mild cognitive impairment at a university-based memory clinic in Brazil
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DOI：
10.1590/s1516-44462008000400008
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发表时间：
2008-12-01
影响因子：
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通讯作者：
Forlenza, Orestes Vicente
中科院分区：
文献类型：
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作者：
Abreu, Izabella Dutra de;Nunes, Paula Villela;Forlenza, Orestes Vicente
目的：探讨简易精神状态检查结合老年认知功能减退知情人问卷对轻度认知功能障碍的诊断准确性。方法：对191名老年人进行简易精神状态检查，对被试进行老年认知功能减退知情人问卷调查。受试者根据他们的认知状态分为三组（对照组：n = 67，轻度认知障碍：n = 65和痴呆：n = 59），这是确定的临床和神经心理学评估。借助ROC曲线检查每个测试在诊断组（轻度认知障碍与对照组、轻度认知障碍与痴呆和痴呆与对照组）区分中的诊断准确性。我们还验证了这两种测试的组合是否会增加轻度认知障碍和对照识别的诊断准确性。结果如下：简易精神状态检查和老年人认知功能减退知情人问卷评分的结合并没有增加简易精神状态检查在识别轻度认知功能障碍患者方面的诊断准确性。结论：目前的数据不足以证明简易精神状态检查和老年人认知功能减退知情人问卷的组合作为轻度认知功能障碍诊断筛查的充分诊断工具。
Objective: To determine the diagnostic accuracy of the Mini-Mental State Examination combined to the Informant Questionnaire on Cognitive Decline in the Elderly for the identification of mild cognitive impairment. Method: 191 elderly subjects were assessed with the Mini-Mental State Examination, and their informants were assessed with the Informant Questionnaire on Cognitive Decline in the Elderly. Subjects were divided into three groups according to their cognitive state (controls: n = 67, mild cognitive impairment: n = 65 and dementia: n = 59), which was ascertained by clinical and neuropsychological evaluation. The diagnostic accuracy of each test in the discrimination of diagnostic groups (mild cognitive impairment vs. controls, mild cognitive impairment vs. dementia and dementia vs. controls) was examined with the aid of ROC curves. We additionally verified if the combination of both tests would increase diagnostic accuracy for mild cognitive impairment and control identification. Results: The combination of the Mini-Mental State Examination and the Informant Questionnaire on Cognitive Decline in the Elderly scores did not increase the Mini-Mental State Examination diagnostic accuracy in the identification of patients with mild cognitive impairment. Conclusions: The present data do not warrant the combination of the Mini-Mental State Examination and the Informant Questionnaire on Cognitive Decline in the Elderly as a sufficient diagnostic tool in the diagnostic screening for mild cognitive impairment.