Do interleukin polymorphisms play a role in the prevention of colorectal adenoma recurrence by dietary flavonols?
Do interleukin polymorphisms play a role in the prevention of colorectal adenoma recurrence by dietary flavonols?
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DOI：
10.1097/cej.0b013e3283429e45
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发表时间：
2011-03-01
影响因子：
2.4
通讯作者：
Cross, Amanda J.
中科院分区：
文献类型：
--
作者：
Bobe, Gerd;Murphy, Gwen;Cross, Amanda J.
黄酮醇等化学预防膳食化合物可能部分通过改变细胞因子表达和减轻炎症来抑制结直肠癌的发生。编码细胞因子的基因启动子区的单核苷酸多态性（SNP）可能影响黄酮醇诱导的细胞因子表达变化，从而影响癌症风险。使用逻辑回归，我们估计了白细胞介素（IL）-1 β，6，8和10的SNP单独或与黄酮醇摄入或血清IL浓度变化相结合与腺瘤复发之间的关联的比值比（OR）和95%置信区间（CI），来自息肉预防试验的干预组的808名参与者，一项为期4年的干预研究，评估低脂、高纤维、高水果和蔬菜饮食对腺瘤复发的有效性。总体而言，编码IL-1 β、6、8和10的基因中的SNP与其相应的血清浓度或腺瘤复发无关。然而，IL-10 - 592 C纯合子个体（OR = 2.23，95%CI：1.07-4.66，P-相互作用= 0.03）或IL-10 - 819 C（OR = 2.18，95% CI：1.05-4.51，P-相互作用= 0.05）在试验期间当他们的血清IL-10浓度升高时，具有高风险腺瘤复发的风险升高。此外，IL-6 - 174 GG联合高于中位数的黄酮醇摄入量（OR = 0.14，95% CI：0.03-0.66）或联合降低的IL-6浓度（OR = 0.14，95% CI：0.03-0.65）降低了晚期腺瘤复发的风险，尽管相互作用项没有统计学显著性。总之，我们的研究结果表明，IL单核苷酸多态性，结合富含黄酮醇的饮食或降低血清IL，可能会降低腺瘤复发的风险。欧洲癌症预防杂志20：86-95（C）2011年Wolters Kluwer Health竖条Lippincott威廉姆斯&威尔金斯。
Chemopreventive dietary compounds, such as flavonols, may inhibit colorectal carcinogenesis partly by altering cytokine expression and attenuating inflammation. Single nucleotide polymorphisms (SNPs) in the promoter regions of genes encoding cytokines may influence flavonol-induced changes in cytokine expression and consequently cancer risk. Using logistic regression, we estimated odds ratios (OR) and 95% confidence intervals (CI) for the association between SNPs of interleukin (IL)-1 beta, 6, 8, and 10 alone or combined with flavonol intake or serum IL concentration changes, and adenoma recurrence in 808 participants from the intervention arm of the Polyp Prevention Trial, a 4-year intervention study evaluating the effectiveness of a low-fat, high-fiber, high-fruit and vegetable diet on adenoma recurrence. Overall, SNPs in genes encoding IL-1 beta, 6, 8, and 10 were not associated with their corresponding serum concentrations or adenoma recurrence. However, individuals homozygous for IL-10 -592 C (OR = 2.23, 95% CI: 1.07-4.66, P-interaction = 0.03) or IL-10 -819 C (OR = 2.18, 95% CI: 1.05-4.51, P-interaction = 0.05) had an elevated risk of high-risk adenoma recurrence when their serum IL-10 concentrations increased during the trial. In addition, IL-6 - 174 GG in combination with above median flavonol intake (OR = 0.14, 95% CI: 0.03-0.66) or with decreased IL-6 concentrations (OR = 0.14, 95% CI: 0.03-0.65) reduced the risk of advanced adenoma recurrence, although the interaction term was not statistically significant. In conclusion, our results suggest that IL SNPs, in combination with a flavonol-rich diet or decreased serum IL, may lower the risk of adenoma recurrence. European Journal of Cancer Prevention 20:86-95 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.