Overexpression of LAPTM4B: an independent prognostic marker in breast cancer
Overexpression of LAPTM4B: an independent prognostic marker in breast cancer
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DOI：
10.1007/s00432-012-1368-y
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发表时间：
2013-04-01
影响因子：
3.6
通讯作者：
Li, Zhigao
中科院分区：
文献类型：
--
作者：
Xiao, Min;Jia, Shusheng;Li, Zhigao
溶酶体相关蛋白跨膜4 β（LAPTM 4 B）是一种新的癌蛋白，已被证明在几种人类恶性肿瘤中过表达。为探讨LAPTM 4 B在乳腺癌中的表达及其意义，采用免疫组化方法检测了35例乳腺良性肿瘤和194例乳腺癌组织中LAPTM 4 B的表达。采用卡方检验分析LAPTM 4 B表达与临床病理参数的相关性。采用Kaplan-Meier和log-rank检验分析患者的生存状况。采用考克斯回归对预后因素进行多因素分析，免疫组化结果显示，乳腺癌组织中LAPTM 4 B的表达水平明显高于良性乳腺肿瘤组织（P < 0.001）。LAPTM 4 B高表达与乳腺癌的TNM分期、淋巴结转移、复发呈正相关。此外，还显示与LAPTM 4 B低表达的患者相比，LAPTM 4 B高表达的患者的总生存期和无病生存期显著较差（分别为P = 0.019和P = 0.005）。多因素考克斯回归分析显示，LAPTM 4 B高表达是乳腺癌患者总生存期和无病生存期的独立预后因素LAPTM 4 B的过表达可能与乳腺癌的进展和预后有关，因此检测LAPTM 4 B的表达将有助于乳腺癌的预后判断。
Lysosome-associated protein transmembrane 4 beta (LAPTM4B), a novel oncoprotein, has been shown to be overexpressed in several human malignancies. Our purpose was to evaluate the expression of LAPTM4B in breast carcinoma and its significance, which was not previously studied by others.Through immunohistochemistry, LAPTM4B expression was evaluated in 35 benign breast tumor specimens and 194 breast cancer specimens. The correlation of LAPTM4B expression with clinicopathological parameters was assessed using chi (2) analysis. The survival status of patients was analyzed using the Kaplan-Meier and log-rank tests. Cox regression was used for the multivariate analysis of prognostic factors.The immunohistochemistry results showed that the expression level of LAPTM4B in breast cancer cases was significantly higher than that in benign breast tumor tissues (P < 0.001). Moreover, statistical analysis also showed that high LAPTM4B expression was positively related to TNM stage, lymph node metastasis, and recurrence. Furthermore, it was also shown that patients with high LAPTM4B expression had significantly poorer overall survival and disease-free survival compared with patients with low expression of LAPTM4B (P = 0.019 and P = 0.005, respectively). Multivariate Cox regression analysis revealed that high LAPTM4B expression level was an independent prognostic factor for both overall survival and disease-free survival of patients with breast cancer (P = 0.041 and P = 0.023, respectively).Overexpression of LAPTM4B may contribute to the tumor progression and poor prognosis of breast cancer, thus testing the expression of LAPTM4B will be helpful for predicting prognosis in breast cancer.