Associations of plasma homocysteine and high-sensitivity C-reactive protein levels with arterial stiffness in Chinese population: a community-based study
Associations of plasma homocysteine and high-sensitivity C-reactive protein levels with arterial stiffness in Chinese population: a community-based study
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DOI：
10.3760/cma.j.issn.0366-6999.2012.01.009
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发表时间：
2012-01-05
影响因子：
6.1
通讯作者：
Bai Jie
中科院分区：
文献类型：
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作者：
Feng Sheng-qiang;Ye Ping;Bai Jie
背景：动脉僵硬度随着年龄的增长而增加，并且与传统的心血管危险因素有关。在华人社区，同型半胱氨酸和高敏c反应蛋白（hs-CRP）与动脉硬化的关系尚不清楚。本研究的目的是在社区队列中调查血浆同型半胱氨酸和hs-CRP水平与动脉僵硬的关系。方法我们将来自中国北京两个社区的1680名参与者的同型半胱氨酸和hs-CRP水平与动脉硬度（颈动脉-股脉波速度（PWV）、颈动脉-桡动脉PWV、颈动脉-踝关节PWV和心率校正增强指数）的四项测量指标联系起来。在生物标志物测量后两天内测量动脉硬度。结果在单因素分析中，同型半胱氨酸与颈动脉-股动脉PWV呈正相关(r=0.211， P
Background Arterial stiffness increases with age and is also associated with traditional cardiovascular risk factors. Little is known about the relations of homocysteine and high-sensitivity C-reactive protein (hs-CRP) to arterial stiffness in the Chinese community. The aim of the present study was to investigate the association of plasma homocysteine and hs-CRP levels with arterial stiffness in a community-based cohort.Methods We related levels of homocysteine and hs-CRP to four measures of arterial stiffness (carotid-femoral pulse wave velocity (PWV), carotid-radial PWV, carotid-ankle PWV and heart rate corrected augmentation index) in 1680 participants from two communities of Beijing, China. Arterial stiffness was measured within two days of the time of biomarker measurement.Results In univariate analysis, homocysteine was positively associated with the carotid-femoral PWV (r=0.211, P