A Role for the Claustrum in Salience Processing?
A Role for the Claustrum in Salience Processing?
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DOI：
10.3389/fnana.2019.00064
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发表时间：
2019-06-19
影响因子：
2.9
通讯作者：
Alloway, Kevin D.
中科院分区：
文献类型：
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作者：
Smith, Jared B.;Watson, Glenn D. R.;Alloway, Kevin D.
屏状核（CLA）是一种皮质下结构，仅存在于哺乳动物中，其功能尚不清楚。先前，在清醒的头部固定大鼠中使用静息态功能性磁共振成像（rs-fMRI），我们发现证据表明CLA是默认模式网络的啮齿动物同系物的一部分（DMN; Smith等人，2017年）。该网络在清醒状态下表现为内侧前额叶皮层（mPFC）、内侧背（MD）丘脑和CLA之间的强大功能联系，而在异氟烷麻醉给药后不存在这种联系。在本报告中，我们回顾了表明啮齿动物CLA也与啮齿动物同源物的显着网络（SN）中鉴定的结构有关的证据，SN是一种将注意力引导到众多感官输入中最相关刺激的回路（塞利等人，2007; Menon and Uddin，2010）.在人类中，这个回路由前扣带皮层（ACC）和包括CLA和岛叶皮层的区域之间的功能连接组成。我们进一步继续审查的相似性和差异之间的功能和解剖连接的CLA和神经解剖学追踪，分别使用RS-fMRI和啮齿类动物。我们详细分析了CLA与扣带皮层的连接，扣带皮层是SN中的一个主要节点，并已被证明可以调节注意力。当考虑到与其他最近的行为和生理学研究，数据揭示了显着性导向中的CLA的作用。更具体地说，我们假设来自mPFC、MD丘脑和基底外侧杏仁核（BLA）的边缘系统信息被CLA整合，以引导运动和感觉皮层的模态相关区域将注意力引向相关（即，突出的）感觉事件。
The claustrum (CLA) is a subcortical structure, present only in mammals, whose function remains uncertain. Previously, using resting-state functional magnetic resonance imaging (rs-fMRI) in awake head-fixed rats, we found evidence that the CLA is part of the rodent homolog of the default mode network (DMN; Smith et al., 2017). This network emerged as strong functional connections between the medial prefrontal cortex (mPFC), mediodorsal (MD) thalamus, and CLA in the awake state, which was not present following administration of isoflurane anesthesia. In the present report, we review evidence indicating that the rodent CLA also has connections with structures identified in the rodent homolog of the salience network (SN), a circuit that directs attention towards the most relevant stimuli among a multitude of sensory inputs (Seeley et al., 2007; Menon and Uddin, 2010). In humans, this circuit consists of functional connections between the anterior cingulate cortex (ACC) and a region that encompasses both the CLA and insular cortex. We further go on to review the similarities and differences between the functional and anatomical connections of the CLA and insula in rodents using both rs-fMRI and neuroanatomical tracing, respectively. We analyze in detail the connectivity of the CLA with the cingulate cortex, which is a major node in the SN and has been shown to modulate attention. When considered with other recent behavior and physiology studies, the data reveal a role for the CLA in salience-guided orienting. More specifically, we hypothesize that limbic information from mPFC, MD thalamus, and the basolateral amygdala (BLA) are integrated by the CLA to guide modality-related regions of motor and sensory cortex in directing attention towards relevant (i.e., salient) sensory events.