Comparison of a novel liquid (Adcon-P®) and a sodium hyaluronate and carboxymethylcellulose membrane (Seprafilm™) in postsurgical adhesion formation in a murine model
Comparison of a novel liquid (Adcon-P®) and a sodium hyaluronate and carboxymethylcellulose membrane (Seprafilm™) in postsurgical adhesion formation in a murine model
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DOI：
10.1007/s10350-004-6523-3
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发表时间：
2003-02-01
影响因子：
3.9
通讯作者：
Fazio, VW
中科院分区：
文献类型：
--
作者：
Oncel, M;Remzi, FH;Fazio, VW
目的：腹腔内应用防粘连膜可减轻粘连的程度和严重程度。术后粘连本研究旨在比较新型液体防粘连屏障与传统片状（Seprafilm（TM））防粘连屏障在小鼠盲肠磨损模型中的有效性。方法：采用正交设计法150只Swiss-Wister小鼠接受剖腹手术和盲肠磨损，并随机分配到Adcon-P（R）（n = 30）或Seprafilm（TM）（n = 30）或对照组（n = 90）。在术后第21天，对小鼠进行再次剖腹术和完全粘连松解术。对分组设盲的研究者使用6分量表对粘连形成的程度和粘连松解术的难度进行评分，范围为0（无粘连）至5（全层肠损伤，伴粘连松解术）。结果报告为中位数（范围）。研究结果：接受Adcon-P（R）（0（范围，0-1））和Seprafilm（TM）（1（范围，0-3））的小鼠中位粘附评分低于对照组小鼠（2（范围，0-5）：两种比较均P < 0.0001）。此外，Adcon-P（R）组的中位粘连评分显著低于Seprafilm（TM）组（P = 0.02）。结论：本研究表明，Adcon-P（R）和Seprafilm（TM）均降低了小鼠盲肠擦伤模型中术后粘连的发生率和粘连松解术的难度。然而，Adcon-P（R）似乎上级于Seprafilm（TM）。该药物是一种有吸引力的器械，需要进一步研究。
PURPOSE: Intra-abdorninal administration of antiadhesive barriers may reduce the extent and severity. of postoperative adhesions. This study aimed to compare the effectiveness of a novel liquid antiadhesive barrier with a conventional sheet (Seprafilm(TM)) antiadhesive barrier in a murine cecal abrasion model. METHODS: One hundred fifty Swiss-Wister mice underwent laparotomy and cecal abrasion and were randomly assigned to receive Adcon-P(R) (n = 30) or Seprafilm(TM) (n = 30) or to a control group (n = 90). At postoperative Day 21, the mice underwent relaparotomy and complete adhesiolysis. An investigator who was blinded to the group assignment scored the extent of adhesion formation and the difficulty of adhesiolysis using a 6-point scale that ranged from 0 (no adhesions) to 5 (full-thickness intestinal injury, with adhesiolysis). Results are reported as median (range). RESULTS: Median adhesion scores in mice receiving Adcon-P(R) (0 (range, 0-1)) and Seprafilm(TM) (1 (range, 0-3)) were lower than in mice in the control group (2 (range, 0-5): P < 0.0001 for both comparisons). In addition, the median adhesion score for the Adcon-P(R) group was significantly lower than that of the Seprafilm(TM) group (P = 0.02). CONCLUSION: This study suggests that both Adcon-P(R) and Seprafilm(TM) decrease the incidence of postoperative adhesions and the difficulty of adhesiolysis in the murine cecal abrasion model. However Adcon-P(R) appeared to be superior to Seprafilm(TM). This agent is an attractive device that requires additional studies.