Altered map of visual space in the superior colliculus of mice lacking early retinal waves
Altered map of visual space in the superior colliculus of mice lacking early retinal waves
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DOI：
10.1523/jneurosci.1555-05.2005
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发表时间：
2005-07-20
影响因子：
5.3
通讯作者：
Hübener, M
中科院分区：
文献类型：
--
作者：
Mrsic-Flogel, TD;Hofer, SB;Hübener, M
在哺乳动物视网膜丘投射的发育过程中，轴突导向分子的梯度分布建立了一个粗略的视网膜定位图。随后细化的最初弥漫投影已被证明取决于空间相关的视网膜神经节细胞的放电。在该方案中，预期图案化视网膜活动的消除不会影响整体视网膜组织，但这尚未被研究。我们使用光学成像的内在信号可视化完整的视网膜定位图在上级丘（SC）的小鼠缺乏早期视网膜波，所造成的缺失的β 2亚基的烟碱乙酰胆碱受体。正如之前在β 2（-/-）小鼠SC中进行的解剖学研究所预期的那样，与野生型小鼠相比，由个体视觉刺激激活的区域要大得多，边界也不那么清晰。然而，重要的是，我们还发现了整个视网膜定位图的系统性扭曲：视觉空间图向前扩展，向后压缩。因此，早期视网膜中的模式化神经元活动对SC的粗糙视网膜组织具有实质性影响。
During the development of the mammalian retinocollicular projection, a coarse retinotopic map is set up by the graded distribution of axon guidance molecules. Subsequent refinement of the initially diffuse projection has been shown to depend on the spatially correlated firing of retinal ganglion cells. In this scheme, the abolition of patterned retinal activity is not expected to influence overall retinotopic organization, but this has not been investigated. We used optical imaging of intrinsic signals to visualize the complete retinotopic map in the superior colliculus (SC) of mice lacking early retinal waves, caused by the deletion of the beta 2 subunit of the nicotinic acetylcholine receptor. As expected from previous anatomical studies in the SC of beta 2(-/-) mice, regions activated by individual visual stimuli were much larger and had less sharp borders than those in wild-type mice. Importantly, however, we also found systematic distortions of the entire retinotopic map: the map of visual space was expanded anteriorly and compressed posteriorly. Thus, patterned neuronal activity in the early retina has a substantial influence on the coarse retinotopic organization of the SC.