Hydro(solvo)thermal in situ ligand syntheses
Hydro(solvo)thermal in situ ligand syntheses
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DOI：
10.1016/j.ccr.2005.01.004
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发表时间：
2005-06
影响因子：
20.6
通讯作者：
Xian‐Ming Zhang
中科院分区：
文献类型：
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作者：
Xian‐Ming Zhang
水（溶剂）热原位配体合成由于其高效、简便和环境友好性，在过去几年中得到了迅速发展。列举了10多种原位配体反应，包括碳碳键形成、羟基化、四唑形成、三唑形成、取代、烷基化、醚键形成、水解、氧化-水解、酰化、胺化和脱羧反应。水热原位配体合成已成为配位化合物晶体工程和有机合成中的一种强有力的方法，并正在成为分离有机异构体的另一种方法。在配位化合物的晶体工程中，原位配体合成法适合于由金属离子和有机前驱体制备新型的配位化合物，并且这些化合物中的大多数不能通过金属离子和配体的直接反应获得。在有机合成中，水热原位配体合成已成为合成常规合成方法难以获得的有机配体的重要途径。在分离有机异构体方面，原位配体合成正成为一种替代途径，因为在某些特殊情况下，在涉及原位配体反应的晶体络合物中仅发现配体的几种异构体中的一种。
Hydro(solvo)thermal in situ ligand synthesis has rapidly developed over the past several years due to its effectiveness, simplicity and environmental friendliness. More than 10 types of in situ ligand reactions have been enumerated, which include carboncarbon bond formation, hydroxylation, tetrazole formation, triazole formation, substitution, alkylation, ether bond formation, hydrolysis, oxidation–hydrolysis, acylation, amination and decarboxylation. Hydrothermal in situ ligand synthesis has become a powerful approach in the crystal engineering of coordination complexes and in organic synthesis, and is becoming an alternative approach in the isolation of organic isomers. In the crystal engineering of coordination complexes, in situ ligand synthesis is suitable to prepare novel coordination complexes from metal ions and organic precursors and most of these complexes are not accessible from a direct reaction of metal ions and ligands. In organic synthesis, hydrothermal in situ ligand syntheses have become very useful pathways to organic ligands, which are difficult to obtain by routine synthetic methods. In isolating organic isomers, in situ ligand synthesis is becoming an alternative route because in some special cases, only one of the several isomers of a ligand is found in crystalline complexes involving in situ ligand reactions.