Effect of Weight Loss after Bariatric Surgery on Skin and the Extracellular Matrix
Effect of Weight Loss after Bariatric Surgery on Skin and the Extracellular Matrix
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DOI：
10.1097/prs.0b013e3181c2a657
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发表时间：
2010-01-01
影响因子：
3.6
通讯作者：
Glasberg, Scot B.
中科院分区：
文献类型：
--
作者：
Light, David;Arvanitis, Georgia M.;Glasberg, Scot B.
背景：肥胖患者的皮肤及其胶原蛋白会发生剧烈的生理和代谢变化。已知减肥手术可显著改善肥胖相关共病和代谢紊乱。本研究的目的是评估皮肤质量减肥手术后，其适用性产生的细胞外基质中使用的reconstructive programmes.Methods：在圆周脂肪切除术，皮肤组织从10例肥胖手术后。对样本进行组织学检查，并通过差示扫描量热法进行研究。患者记录的回顾性审查被用来确定减肥和身体提升程序之间的时间，并确定受试者的人口统计学和临床数据，包括体重指数，多余的体重减轻，和共病conditions.Results：整形手术减肥手术后20.5 +/- 11个月，和患者经历了132.1 +/- 61.0磅的平均体重减轻。减肥手术后皮肤样本的组织学评价显示，在肉眼可见的正常区域内，胶原结构组织不良，弹性蛋白降解和瘢痕形成区域。差示扫描量热法显示增加的相变焓和降低的起始温度的胶原蛋白变性的纹膨胀样品相比，散装肥胖的皮肤样品，一致的组织基质降解striae.Conclusion：在这个病人群体的皮肤组织表现出显着的迹象，尽管持续时间的细胞外基质成分的损害，因为肥胖的程序。（Plast。重建125：343，2010）。
Background: Obese patients experience dramatic physical and metabolic changes in the skin and its collagen. Bariatric surgery is known to result in significant improvement in obesity-associated comorbid conditions and metabolic disturbances. The aim of this study was to evaluate skin quality following weight loss surgery and its suitability to produce an extracellular matrix for use in reconstructive procedures.Methods: During circumferential lipectomy, skin tissue was obtained from 10 patients following bariatric surgery. The samples were subjected to histologic examination and to study by differential scanning calorimetry. A retrospective review of patient records was used to determine time between bariatric and body lift procedures and to identify subject demographic and clinical data, including body mass index, excess weight loss, and comorbid conditions.Results: Plastic surgery followed bariatric surgery by 20.5 +/- 11 months, and patients experienced an average weight loss of 132.1 +/- 61.0 lb. Histologic evaluation of post-bariatric surgery skin samples showed a poorly organized collagen structure, elastin degradation, and regions of scar formation within macroscopically normal areas. Differential scanning calorimetry showed increased enthalpy of phase transition and decreased onset temperature for collagen denaturation in striae distensae samples compared with bulk bariatric skin samples, consistent with tissue matrix degradation in striae.Conclusion: Skin tissue in this patient population exhibited significant signs of damage to extracellular matrix components despite the duration of time since the bariatric procedure. (Plast. Reconstr. Surg. 125: 343, 2010.)