Heat acclimation in cystic fibrosis.
Heat acclimation in cystic fibrosis.
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囊性纤维化的热适应。
DOI：
10.1152/jappl.1984.57.2.408
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
C. Green
中科院分区：
文献类型：
--
作者：
D. Orenstein;K. Henke;C. Green
囊性纤维化（CF）患者可能有中暑的风险，因为他们的汗液氯化物和钠浓度（[Cl-]，[Na+]）高，但尚不清楚他们是否能热适应。我们研究了10名CF患者和10名正常对照者在高温（37摄氏度干球，24-29摄氏度湿球）下连续8天的周期运动。两组均适应环境。CF直肠温度峰值（Tre）第1天为38.2 +/- 0.3 ℃，第8天为37.8 +/- 0.4 ℃（P <0.005），心率峰值（HR）第1天为151 +/- 24次/min，第8天为136 +/- 22次/min（P <0.025）。对照温度（T）和HR相似。对照组汗液[Cl-]从第1天的37.2 +/- 14.6 meq/l降至第8天的24.9 +/- 10.6 meq/l（P <0.005）。CF汗液[Cl-]显著更高，并且不随适应而变化（第1天，71.1 +/- 20.9 meq/l;第8天，72.6 +/- 21.6 meq/l，NS）。在适应前后，运动热训练导致CF患者血清[Cl-]显著降低（第1天104.5 +/- 4.6至101.3 +/- 4.4 meq/l，P <0.05;第8天103.5 +/- 5.1至99.7 +/- 4.2 meq/l，P <0.025），但对照组中没有。CF组的血清[Cl-]在每次测量时均显著低于对照组。两组在两天的运动后都有显著的肾脏Na+保护。（250字处删节）
Cystic fibrosis (CF) patients may be at risk for heat illness because of their high sweat chloride and sodium concentrations ([Cl-], [Na+]), but it is not known if they can heat acclimate. We studied 10 CF patients and 10 normal controls on 8 consecutive days of cycle exercise in the heat (37 degrees C dry bulb, 24-29 degrees C wet bulb). Both groups acclimated. CF peak rectal temperature (Tre) was 38.2 +/- 0.3 degrees C on day 1 and 37.8 +/- 0.4 degrees C on day 8 (P less than .005), and peak heart rates (HR) were 151 +/- 24 beats/min on day 1 and 136 +/- 22 beats/min on day 8 (P less than 0.025). Control temperature (T) and HR were similar. Controls decreased sweat [Cl-] from 37.2 +/- 14.6 meq/l on day 1 and to 24.9 +/- 10.6 meq/l on day 8 (P less than 0.005). CF sweat [Cl-] was significantly higher and did not change with acclimation (day 1, 71.1 +/- 20.9 meq/l; day 8, 72.6 +/- 21.6 meq/l, NS). Before and after acclimation, exercise-heat sessions resulted in significant decreases in serum [Cl-] in CF patients (104.5 +/- 4.6 to 101.3 +/- 4.4 meq/l on day 1, P less than 0.05; 103.5 +/- 5.1 to 99.7 +/- 4.2 meq/l on day 8, P less than 0.025) but not in controls. Serum [Cl-] was significantly lower in CF than control subjects at every measurement. Both groups had significant renal Na+ conservation after exercise on both days.(ABSTRACT TRUNCATED AT 250 WORDS)